Persistent pulmonary hypertension of the newborn associated with severe congenital anemia of various etiologies

Danielle Landau, Josef Kapelushnik, Miri B. Harush, Kyla Marks, Hanna Shalev

Research output: Contribution to journalArticlepeer-review

8 Scopus citations


Among the many associated features of persistent pulmonary hypertension of the neonate (PPHN), severe congenital anemia has been described only occasionally and is not included in the list of conditions that may cause PPHN in the neonate. We describe the clinical course of a group of 12 full-term neonates with PPHN and congenital anemia due to congenital dyserythropoietic anemia (7/12), α thalasemia (1/12), Diamond-Blackfan (1/12), and epsilon gamma delta beta thalassemia (3/12). The association of congenital anemia and PPHN is more common than previously thought; it can exist with various etiologies and severity of anemia. Congenital anemia has not been described until now as a cause or risk factor for PPHN; it should be considered as such alone or in combination with other known causes to be recognized early and treated appropriately to improve outcome. In families with known cases of congenital anemia due to the above-mentioned diagnosis, closer prenatal follow-up should be offered to anticipate possible fetal distress and/or fetal anemia and PPHN after birth.

Original languageEnglish
Pages (from-to)60-62
Number of pages3
JournalJournal of Pediatric Hematology/Oncology
Issue number1
StatePublished - 3 Jan 2015
Externally publishedYes


  • congenital anemia
  • newborn
  • pulmonary hypertension

ASJC Scopus subject areas

  • Pediatrics, Perinatology, and Child Health
  • Hematology
  • Oncology


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