TY - JOUR
T1 - Personality disorders predict onset of axis I disorders and impaired functioning among homosexual men with and at risk of HIV infection
AU - Johnson, Jeffrey G.
AU - Williams, Janet B.W.
AU - Goetz, Raymond R.
AU - Rabkin, Judith G.
AU - Remien, Robert H.
AU - Lipsitz, Joshua D.
AU - Gorman, Jack M.
PY - 1996/1/1
Y1 - 1996/1/1
N2 - Background: A longitudinal study was conducted to investigate whether personality disorders (PDs) increase risk for the development of future Axis I disorders and serious functional impairment among human immunodeficiency virus (HIV)-seropositive and HIV-seronegative homosexual men. Method: Baseline assessments of PDs, Axis I disorders anti symptoms, and Global Assessments of Functioning were conducted with a community sample of 107 (66 HIV-positive and 41 HIV-negative) homosexual men participating in a longitudinal study with semiannual interviews over 3 years. Results: Logistic regression analysis indicated that PDs predicted onset of subsequent Axis I disorders after con trolling for both HIV status and lifetime Axis I history (adjusted odds ratio, 4.31; P=.01; 95% confidence interval, 1.39 to 13.32). Of the 21 participants with PDs, 16 (76%) were subsequently diagnosed with Axis I disorders on at least one occasion. By contrast, only 36 (42%) of the 86 participants without PDs were subsequently diagnosed with Axis I disorders. Further, 33% of the participants with PDs, in comparison with only 8% of those without PDs, were assigned Global Assessments of Functioning scores of 50 or lower, indicating serious impairment during the postbaseline study period (adjusted odds ratio, 5.70; P<.005; 95% confidence interval, 1.66 to 19.53). Conclusion: Personality disorders may contribute to increased risk for onset of Axis I disorders and serious impairment among homosexual men regardless of HIV serologic status.
AB - Background: A longitudinal study was conducted to investigate whether personality disorders (PDs) increase risk for the development of future Axis I disorders and serious functional impairment among human immunodeficiency virus (HIV)-seropositive and HIV-seronegative homosexual men. Method: Baseline assessments of PDs, Axis I disorders anti symptoms, and Global Assessments of Functioning were conducted with a community sample of 107 (66 HIV-positive and 41 HIV-negative) homosexual men participating in a longitudinal study with semiannual interviews over 3 years. Results: Logistic regression analysis indicated that PDs predicted onset of subsequent Axis I disorders after con trolling for both HIV status and lifetime Axis I history (adjusted odds ratio, 4.31; P=.01; 95% confidence interval, 1.39 to 13.32). Of the 21 participants with PDs, 16 (76%) were subsequently diagnosed with Axis I disorders on at least one occasion. By contrast, only 36 (42%) of the 86 participants without PDs were subsequently diagnosed with Axis I disorders. Further, 33% of the participants with PDs, in comparison with only 8% of those without PDs, were assigned Global Assessments of Functioning scores of 50 or lower, indicating serious impairment during the postbaseline study period (adjusted odds ratio, 5.70; P<.005; 95% confidence interval, 1.66 to 19.53). Conclusion: Personality disorders may contribute to increased risk for onset of Axis I disorders and serious impairment among homosexual men regardless of HIV serologic status.
UR - http://www.scopus.com/inward/record.url?scp=0029866191&partnerID=8YFLogxK
U2 - 10.1001/archpsyc.1996.01830040086013
DO - 10.1001/archpsyc.1996.01830040086013
M3 - Article
C2 - 8634013
AN - SCOPUS:0029866191
VL - 53
SP - 350
EP - 357
JO - JAMA Psychiatry
JF - JAMA Psychiatry
SN - 2168-622X
IS - 4
ER -
