Perturbation of lymphocyte response to concanavalin A by exogenous cholesterol and lecithin

B. Rivnay, Amiela Globerson, M. Shinitzky

Research output: Contribution to journalArticlepeer-review

48 Scopus citations

Abstract

Incubation of lymphocytes with lecithin liposomes enriched with cholesterol, elevated the cholesterol level of the cells relative to phospholipids. Treatment of lymphocytes with pure lecithin liposomes resulted in the converse effect. Both these treatments resulted in suppression of the induction phase of the response to concanavalin A and were practically reversible. It is suggested that these changes induce modulations of the fluidity of the lymphocyte membrane which may also take place in vivo by serum lipoproteins. Based on this study, the possible effects of lipids on lymphocyte activation are discussed.

Original languageEnglish
Pages (from-to)185-189
Number of pages5
JournalEuropean Journal of Immunology
Volume8
Issue number3
DOIs
StatePublished - 1 Jan 1978
Externally publishedYes

ASJC Scopus subject areas

  • Immunology and Allergy
  • Immunology

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