PH-Sensitive Interactions between Cellulose Nanocrystals and DOPC Liposomes

Yotam Navon; Harisoa Radavidson; Jean Luc Putaux; Bruno Jean; Laurent Heux

doi:10.1021/acs.biomac.7b00872

PH-Sensitive Interactions between Cellulose Nanocrystals and DOPC Liposomes

Yotam Navon, Harisoa Radavidson, Jean Luc Putaux, Bruno Jean, Laurent Heux

Research output: Contribution to journal › Article › peer-review

34 Scopus citations

Abstract

The interaction of 1,2 dioleolyl-sn-glycero-3-phosphatidylcholine (DOPC) vesicles with cellulose nanocrystals (CNCs) using several complementary techniques. Dynamic light scattering, zeta-potential, cryo-transmission electron microscopy and isothermal titration calorimetry (ITC) analyses confirmed the formation of pH-dependent CNC-liposome complexes. ITC was used to characterize the thermodynamic properties of this interaction. Positive values of enthalpy were found at pH lower than 5 where the charge sign of the constituents was opposite. The association was more pronounced at lower pH, as indicated by the higher values of association constant. We suggest that the positive enthalpy is derived from the release of counterions from the particle hydration shell during the association and that the charge of the vesicles plays a significant role in this interaction.

Original language	English
Pages (from-to)	2918-2927
Number of pages	10
Journal	Biomacromolecules
Volume	18
Issue number	9
DOIs	https://doi.org/10.1021/acs.biomac.7b00872
State	Published - 11 Sep 2017
Externally published	Yes

ASJC Scopus subject areas

Bioengineering
Biomaterials
Polymers and Plastics
Materials Chemistry

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title = "PH-Sensitive Interactions between Cellulose Nanocrystals and DOPC Liposomes",

abstract = "The interaction of 1,2 dioleolyl-sn-glycero-3-phosphatidylcholine (DOPC) vesicles with cellulose nanocrystals (CNCs) using several complementary techniques. Dynamic light scattering, zeta-potential, cryo-transmission electron microscopy and isothermal titration calorimetry (ITC) analyses confirmed the formation of pH-dependent CNC-liposome complexes. ITC was used to characterize the thermodynamic properties of this interaction. Positive values of enthalpy were found at pH lower than 5 where the charge sign of the constituents was opposite. The association was more pronounced at lower pH, as indicated by the higher values of association constant. We suggest that the positive enthalpy is derived from the release of counterions from the particle hydration shell during the association and that the charge of the vesicles plays a significant role in this interaction.",

author = "Yotam Navon and Harisoa Radavidson and Putaux, {Jean Luc} and Bruno Jean and Laurent Heux",

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T1 - PH-Sensitive Interactions between Cellulose Nanocrystals and DOPC Liposomes

AU - Navon, Yotam

AU - Radavidson, Harisoa

AU - Putaux, Jean Luc

AU - Jean, Bruno

AU - Heux, Laurent

PY - 2017/9/11

Y1 - 2017/9/11

N2 - The interaction of 1,2 dioleolyl-sn-glycero-3-phosphatidylcholine (DOPC) vesicles with cellulose nanocrystals (CNCs) using several complementary techniques. Dynamic light scattering, zeta-potential, cryo-transmission electron microscopy and isothermal titration calorimetry (ITC) analyses confirmed the formation of pH-dependent CNC-liposome complexes. ITC was used to characterize the thermodynamic properties of this interaction. Positive values of enthalpy were found at pH lower than 5 where the charge sign of the constituents was opposite. The association was more pronounced at lower pH, as indicated by the higher values of association constant. We suggest that the positive enthalpy is derived from the release of counterions from the particle hydration shell during the association and that the charge of the vesicles plays a significant role in this interaction.

AB - The interaction of 1,2 dioleolyl-sn-glycero-3-phosphatidylcholine (DOPC) vesicles with cellulose nanocrystals (CNCs) using several complementary techniques. Dynamic light scattering, zeta-potential, cryo-transmission electron microscopy and isothermal titration calorimetry (ITC) analyses confirmed the formation of pH-dependent CNC-liposome complexes. ITC was used to characterize the thermodynamic properties of this interaction. Positive values of enthalpy were found at pH lower than 5 where the charge sign of the constituents was opposite. The association was more pronounced at lower pH, as indicated by the higher values of association constant. We suggest that the positive enthalpy is derived from the release of counterions from the particle hydration shell during the association and that the charge of the vesicles plays a significant role in this interaction.

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PH-Sensitive Interactions between Cellulose Nanocrystals and DOPC Liposomes

Abstract

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