Pharmacokinetics of valproic acid in volunteers after a single dose study

Meir Bialer; Ziad Hussein; Itamar Raz; Oded Abramsky; Yuval Herishanu; Freddy Pachys

doi:10.1002/bdd.2510060105

Pharmacokinetics of valproic acid in volunteers after a single dose study

Meir Bialer, Ziad Hussein, Itamar Raz, Oded Abramsky, Yuval Herishanu, Freddy Pachys

Research output: Contribution to journal › Article › peer-review

14 Scopus citations

Abstract

The pharmacokinetics of valproic acid (VPA) was investigated in six healthy volunteers. This was done by monitoring total and free (unbound) valproic acid levels in the serum, and the amount of one of its metabolites, VPA glucuronide, in the urine as a function of time, after a single dose administration of the parent drug. VPA half‐life calculated from the urine data of the metabolite was shorter than the half‐life calculated from the blood data. About 15 to 20 per cent of the administered oral dose of VPA was excreted in the urine as VPA glucuronide. The average free fraction of VPA obtained in this study, by using the EMIT technique, ranged from 1.5 to 11.5 per cent with a mean value of 4.9 per cent.

Original language	English
Pages (from-to)	33-42
Number of pages	10
Journal	Biopharmaceutics and Drug Disposition
Volume	6
Issue number	1
DOIs	https://doi.org/10.1002/bdd.2510060105
State	Published - 1 Jan 1985

Keywords

EMIT
Free drug levels
Pharmacokinetics
Valproic acid
Valproic acid glucuronide

ASJC Scopus subject areas

Pharmacology
Pharmaceutical Science
Pharmacology (medical)

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10.1002/bdd.2510060105

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abstract = "The pharmacokinetics of valproic acid (VPA) was investigated in six healthy volunteers. This was done by monitoring total and free (unbound) valproic acid levels in the serum, and the amount of one of its metabolites, VPA glucuronide, in the urine as a function of time, after a single dose administration of the parent drug. VPA half‐life calculated from the urine data of the metabolite was shorter than the half‐life calculated from the blood data. About 15 to 20 per cent of the administered oral dose of VPA was excreted in the urine as VPA glucuronide. The average free fraction of VPA obtained in this study, by using the EMIT technique, ranged from 1.5 to 11.5 per cent with a mean value of 4.9 per cent.",

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AU - Bialer, Meir

AU - Hussein, Ziad

AU - Raz, Itamar

AU - Abramsky, Oded

AU - Herishanu, Yuval

AU - Pachys, Freddy

PY - 1985/1/1

Y1 - 1985/1/1

N2 - The pharmacokinetics of valproic acid (VPA) was investigated in six healthy volunteers. This was done by monitoring total and free (unbound) valproic acid levels in the serum, and the amount of one of its metabolites, VPA glucuronide, in the urine as a function of time, after a single dose administration of the parent drug. VPA half‐life calculated from the urine data of the metabolite was shorter than the half‐life calculated from the blood data. About 15 to 20 per cent of the administered oral dose of VPA was excreted in the urine as VPA glucuronide. The average free fraction of VPA obtained in this study, by using the EMIT technique, ranged from 1.5 to 11.5 per cent with a mean value of 4.9 per cent.

AB - The pharmacokinetics of valproic acid (VPA) was investigated in six healthy volunteers. This was done by monitoring total and free (unbound) valproic acid levels in the serum, and the amount of one of its metabolites, VPA glucuronide, in the urine as a function of time, after a single dose administration of the parent drug. VPA half‐life calculated from the urine data of the metabolite was shorter than the half‐life calculated from the blood data. About 15 to 20 per cent of the administered oral dose of VPA was excreted in the urine as VPA glucuronide. The average free fraction of VPA obtained in this study, by using the EMIT technique, ranged from 1.5 to 11.5 per cent with a mean value of 4.9 per cent.

KW - EMIT

KW - Free drug levels

KW - Pharmacokinetics

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KW - Valproic acid glucuronide

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Pharmacokinetics of valproic acid in volunteers after a single dose study

Abstract

Keywords

ASJC Scopus subject areas

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