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Pharmacological restoration of GTP hydrolysis by mutant RAS
Antonio Cuevas-Navarro
, Yasin Pourfarjam
, Feng Hu
, Diego J. Rodriguez
, Alberto Vides
, Ben Sang
, Shijie Fan
, Yehuda Goldgur
, Elisa de Stanchina
, Piro Lito
Research output
:
Contribution to journal
›
Article
›
peer-review
40
Scopus citations
Overview
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Keyphrases
GTP Hydrolysis
100%
GTPase Activity
100%
RAS mutant
100%
Cyclophilin A
66%
Phosphate
33%
Therapeutic Effect
33%
Downstream Signaling
33%
Cancer Growth
33%
Pathogenic mutations
33%
Active State
33%
Nucleophilic Attack
33%
Mutation Specific
33%
Hydrolase Activity
33%
Molecular Glue
33%
Complex Inhibitor
33%
Proto-oncogene
33%
Dual Mechanism of Action
33%
Pharmacological Stimulation
33%
Biochemistry, Genetics and Molecular Biology
Enzymatic Hydrolysis
100%
Guanosine Triphosphate
100%
GTPase
75%
Cyclophilin
50%
Proto Oncogene
25%
Hydrolase
25%
KRAS
25%
Nucleophilicity
25%
Pharmacological Stimulation
25%
HRAS
25%
Molecular Glue
25%
Pharmacology, Toxicology and Pharmaceutical Science
Guanosine Triphosphate
100%
Guanosine Triphosphatase
100%
Cyclophilin A
66%
Therapeutic Effect
33%
Hydrolase
33%
Cancer Growth
33%
Pharmacological Stimulation
33%