TY - JOUR
T1 - Phenytoin as an Augmentation for SSRI Failures
T2 - A Small Controlled Study
AU - Shapira, B.
AU - Nemets, B.
AU - Trachtenberg, A.
AU - Belmaker, R. H.
N1 - Funding Information:
This work was supported by a grant from the Dreyfus Health Foundation (BN) and the Schonbaum Foundation (BS).
PY - 2006
Y1 - 2006
N2 - Background: Lithium augmentation of antidepressant effects in patients unimproved on antidepressants is well documented. We hypothesized that phenytoin, reported to have antimanic, antidepressant and prophylactic effects on affective disorder, might also augment in SSRI failures. Methods: Twenty five patients were recruited and twenty had data sufficient for analysis between phenytoin and placebo in depression ratings. Results: No effect was found. Limitations: This study was a small study. Conclusions: Lithium's ability to augment in antidepressant failures may not be shared with the anticonvulsant mood stabilizers.
AB - Background: Lithium augmentation of antidepressant effects in patients unimproved on antidepressants is well documented. We hypothesized that phenytoin, reported to have antimanic, antidepressant and prophylactic effects on affective disorder, might also augment in SSRI failures. Methods: Twenty five patients were recruited and twenty had data sufficient for analysis between phenytoin and placebo in depression ratings. Results: No effect was found. Limitations: This study was a small study. Conclusions: Lithium's ability to augment in antidepressant failures may not be shared with the anticonvulsant mood stabilizers.
KW - Lithium augmentation
KW - Phenytoin
KW - SSRI
UR - http://www.scopus.com/inward/record.url?scp=33749639033&partnerID=8YFLogxK
U2 - 10.1016/j.jad.2006.05.011
DO - 10.1016/j.jad.2006.05.011
M3 - Article
AN - SCOPUS:33749639033
VL - 96
SP - 123
EP - 126
JO - Journal of Affective Disorders
JF - Journal of Affective Disorders
SN - 0165-0327
IS - 1-2
ER -
