Phenytoin as an augmentation for SSRI failures: A small controlled study

B. Shapira; B. Nemets; A. Trachtenberg; R. H. Belmaker

doi:10.1016/j.jad.2006.05.011

Phenytoin as an augmentation for SSRI failures: A small controlled study

B. Shapira, B. Nemets, A. Trachtenberg, R. H. Belmaker

Research output: Contribution to journal › Article › peer-review

10 Scopus citations

Abstract

Background: Lithium augmentation of antidepressant effects in patients unimproved on antidepressants is well documented. We hypothesized that phenytoin, reported to have antimanic, antidepressant and prophylactic effects on affective disorder, might also augment in SSRI failures. Methods: Twenty five patients were recruited and twenty had data sufficient for analysis between phenytoin and placebo in depression ratings. Results: No effect was found. Limitations: This study was a small study. Conclusions: Lithium's ability to augment in antidepressant failures may not be shared with the anticonvulsant mood stabilizers.

Original language	English
Pages (from-to)	123-126
Number of pages	4
Journal	Journal of Affective Disorders
Volume	96
Issue number	1-2
DOIs	https://doi.org/10.1016/j.jad.2006.05.011
State	Published - 1 Nov 2006
Externally published	Yes

Keywords

Lithium augmentation
Phenytoin
SSRI

ASJC Scopus subject areas

Clinical Psychology
Psychiatry and Mental health

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10.1016/j.jad.2006.05.011

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title = "Phenytoin as an augmentation for SSRI failures: A small controlled study",

abstract = "Background: Lithium augmentation of antidepressant effects in patients unimproved on antidepressants is well documented. We hypothesized that phenytoin, reported to have antimanic, antidepressant and prophylactic effects on affective disorder, might also augment in SSRI failures. Methods: Twenty five patients were recruited and twenty had data sufficient for analysis between phenytoin and placebo in depression ratings. Results: No effect was found. Limitations: This study was a small study. Conclusions: Lithium's ability to augment in antidepressant failures may not be shared with the anticonvulsant mood stabilizers.",

keywords = "Lithium augmentation, Phenytoin, SSRI",

author = "B. Shapira and B. Nemets and A. Trachtenberg and Belmaker, {R. H.}",

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doi = "10.1016/j.jad.2006.05.011",

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journal = "Journal of Affective Disorders",

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T1 - Phenytoin as an augmentation for SSRI failures

T2 - A small controlled study

AU - Shapira, B.

AU - Nemets, B.

AU - Trachtenberg, A.

AU - Belmaker, R. H.

PY - 2006/11/1

Y1 - 2006/11/1

N2 - Background: Lithium augmentation of antidepressant effects in patients unimproved on antidepressants is well documented. We hypothesized that phenytoin, reported to have antimanic, antidepressant and prophylactic effects on affective disorder, might also augment in SSRI failures. Methods: Twenty five patients were recruited and twenty had data sufficient for analysis between phenytoin and placebo in depression ratings. Results: No effect was found. Limitations: This study was a small study. Conclusions: Lithium's ability to augment in antidepressant failures may not be shared with the anticonvulsant mood stabilizers.

AB - Background: Lithium augmentation of antidepressant effects in patients unimproved on antidepressants is well documented. We hypothesized that phenytoin, reported to have antimanic, antidepressant and prophylactic effects on affective disorder, might also augment in SSRI failures. Methods: Twenty five patients were recruited and twenty had data sufficient for analysis between phenytoin and placebo in depression ratings. Results: No effect was found. Limitations: This study was a small study. Conclusions: Lithium's ability to augment in antidepressant failures may not be shared with the anticonvulsant mood stabilizers.

KW - Lithium augmentation

KW - Phenytoin

KW - SSRI

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DO - 10.1016/j.jad.2006.05.011

M3 - Article

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AN - SCOPUS:33749639033

SN - 0165-0327

VL - 96

SP - 123

EP - 126

JO - Journal of Affective Disorders

JF - Journal of Affective Disorders

IS - 1-2

ER -

Phenytoin as an augmentation for SSRI failures: A small controlled study

Abstract

Keywords

ASJC Scopus subject areas

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