Cutaneous drug reactions are attributed usually to one culprit drug, however, some CDRs1 may be associated with drug interactions. To present a case series of four patients with phenytoin-induced severe CDRs, including toxic epidermal necrolysis (2 patients), exanthematous eruption (1 patient) and hypersensitivity syndrome (1 patient). In all patients the reactions appeared following the combined intake of phenytoin, corticosteroids and H2-blockers. Our case series may imply the role of drug interactions between phenytoin, corticosteroids and H2-blockers in the induction of severe CDRs.
|Number of pages||3|
|Journal||Israel Medical Association Journal|
|State||Published - 1 Dec 1999|
- Brain neoplasms
- Cutaneous drug reactions
- Hypersensitivity syndrome
- Toxic epidermal necrolysis