Phenytoin-induced severe cutaneous drug reactions: Suspected interactions with corticosteroids and H2-blockers

Arnon D. Cohen, Eli Reichental, Sima Halevy

Research output: Contribution to journalArticlepeer-review

9 Scopus citations

Abstract

Cutaneous drug reactions are attributed usually to one culprit drug, however, some CDRs1 may be associated with drug interactions. To present a case series of four patients with phenytoin-induced severe CDRs, including toxic epidermal necrolysis (2 patients), exanthematous eruption (1 patient) and hypersensitivity syndrome (1 patient). In all patients the reactions appeared following the combined intake of phenytoin, corticosteroids and H2-blockers. Our case series may imply the role of drug interactions between phenytoin, corticosteroids and H2-blockers in the induction of severe CDRs.

Original languageEnglish
Pages (from-to)95-97
Number of pages3
JournalIsrael Medical Association Journal
Volume1
Issue number2
StatePublished - 1 Dec 1999

Keywords

  • Brain neoplasms
  • Corticosteroids
  • Cutaneous drug reactions
  • H-blockers
  • Hypersensitivity syndrome
  • Phenytoin
  • Toxic epidermal necrolysis

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