Phenytoin-induced severe cutaneous drug reactions: Suspected interactions with corticosteroids and H₂-blockers

Cutaneous drug reactions are attributed usually to one culprit drug, however, some CDRs¹ may be associated with drug interactions. To present a case series of four patients with phenytoin-induced severe CDRs, including toxic epidermal necrolysis (2 patients), exanthematous eruption (1 patient) and hypersensitivity syndrome (1 patient). In all patients the reactions appeared following the combined intake of phenytoin, corticosteroids and H₂-blockers. Our case series may imply the role of drug interactions between phenytoin, corticosteroids and H₂-blockers in the induction of severe CDRs.