Phloroglucinol-based biomimetic adhesives for medical applications

Ronit Bitton; Elinor Josef; Irena Shimshelashvili; Keren Shapira; Dror Seliktar; Havazelet Bianco-Peled

doi:10.1016/j.actbio.2008.10.004

Phloroglucinol-based biomimetic adhesives for medical applications

Ronit Bitton, Elinor Josef, Irena Shimshelashvili, Keren Shapira, Dror Seliktar, Havazelet Bianco-Peled

Research output: Contribution to journal › Article › peer-review

33 Scopus citations

Abstract

An adhesive that functions well under moist conditions could facilitate many surgical procedures. In recent studies we designed novel biomimetic glues which mimic the adhesion mechanism of algae, renowned for their remarkable adherence to wet surfaces. Here we extend our previous studies and propose biomimetic formulations, composed of alginate gel and native phloroglucinol, that do not induce cell cytotoxicity. Characterization of the adherence to tissues showed that adhesion was directly related to the mechanical strength of the cross-linked alginate. Therefore the adhesion strength can be altered by changing the source of the calcium cross-linker, the alginate G-content or the molecular weight of the alginate. The adhesion strength was comparable to that of Tisseel^™, a commercial tissue adhesive.

Original language	English
Pages (from-to)	1582-1587
Number of pages	6
Journal	Acta Biomaterialia
Volume	5
Issue number	5
DOIs	https://doi.org/10.1016/j.actbio.2008.10.004
State	Published - 1 Jan 2009
Externally published	Yes

Keywords

Alginate
Biocompatibility
Biomimetic
Phloroglucinol
Tissue adhesive

ASJC Scopus subject areas

Biotechnology
Biomaterials
Biochemistry
Biomedical Engineering
Molecular Biology

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10.1016/j.actbio.2008.10.004

Cite this

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title = "Phloroglucinol-based biomimetic adhesives for medical applications",

abstract = "An adhesive that functions well under moist conditions could facilitate many surgical procedures. In recent studies we designed novel biomimetic glues which mimic the adhesion mechanism of algae, renowned for their remarkable adherence to wet surfaces. Here we extend our previous studies and propose biomimetic formulations, composed of alginate gel and native phloroglucinol, that do not induce cell cytotoxicity. Characterization of the adherence to tissues showed that adhesion was directly related to the mechanical strength of the cross-linked alginate. Therefore the adhesion strength can be altered by changing the source of the calcium cross-linker, the alginate G-content or the molecular weight of the alginate. The adhesion strength was comparable to that of Tisseel{\texttrademark}, a commercial tissue adhesive.",

keywords = "Alginate, Biocompatibility, Biomimetic, Phloroglucinol, Tissue adhesive",

author = "Ronit Bitton and Elinor Josef and Irena Shimshelashvili and Keren Shapira and Dror Seliktar and Havazelet Bianco-Peled",

note = "Funding Information: The financial support by the Yeshaya Horowitz Association is gratefully acknowledged. ",

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T1 - Phloroglucinol-based biomimetic adhesives for medical applications

AU - Bitton, Ronit

AU - Josef, Elinor

AU - Shimshelashvili, Irena

AU - Shapira, Keren

AU - Seliktar, Dror

AU - Bianco-Peled, Havazelet

N1 - Funding Information: The financial support by the Yeshaya Horowitz Association is gratefully acknowledged.

PY - 2009/1/1

Y1 - 2009/1/1

N2 - An adhesive that functions well under moist conditions could facilitate many surgical procedures. In recent studies we designed novel biomimetic glues which mimic the adhesion mechanism of algae, renowned for their remarkable adherence to wet surfaces. Here we extend our previous studies and propose biomimetic formulations, composed of alginate gel and native phloroglucinol, that do not induce cell cytotoxicity. Characterization of the adherence to tissues showed that adhesion was directly related to the mechanical strength of the cross-linked alginate. Therefore the adhesion strength can be altered by changing the source of the calcium cross-linker, the alginate G-content or the molecular weight of the alginate. The adhesion strength was comparable to that of Tisseel™, a commercial tissue adhesive.

AB - An adhesive that functions well under moist conditions could facilitate many surgical procedures. In recent studies we designed novel biomimetic glues which mimic the adhesion mechanism of algae, renowned for their remarkable adherence to wet surfaces. Here we extend our previous studies and propose biomimetic formulations, composed of alginate gel and native phloroglucinol, that do not induce cell cytotoxicity. Characterization of the adherence to tissues showed that adhesion was directly related to the mechanical strength of the cross-linked alginate. Therefore the adhesion strength can be altered by changing the source of the calcium cross-linker, the alginate G-content or the molecular weight of the alginate. The adhesion strength was comparable to that of Tisseel™, a commercial tissue adhesive.

KW - Alginate

KW - Biocompatibility

KW - Biomimetic

KW - Phloroglucinol

KW - Tissue adhesive

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U2 - 10.1016/j.actbio.2008.10.004

DO - 10.1016/j.actbio.2008.10.004

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SN - 1742-7061

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SP - 1582

EP - 1587

JO - Acta Biomaterialia

JF - Acta Biomaterialia

IS - 5

ER -

Phloroglucinol-based biomimetic adhesives for medical applications

Abstract

Keywords

ASJC Scopus subject areas

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