Phorbol ester intracerebroventricularly induces a behavioral hypoactivity that is not affected by chronic or acute lithium

Y. Patishi, Y. Bersudsky, R. H. Belmaker

Research output: Contribution to journalArticlepeer-review

4 Scopus citations

Abstract

Chronic lithium treatment in rats has been reported to decrease protein kinase C α isozyme in hippocampal membranes. We gave phorbol ester, a protein kinase C activator, i.c.v. to rats treated with acute or chronic lithium. Low dose phorbol ester causes a marked hypoactivity and high dose phorbol ester causes a barrel rolling behavior, but no behavioral interactions with lithium treatment were observed.

Original languageEnglish
Pages (from-to)39-41
Number of pages3
JournalEuropean Neuropsychopharmacology
Volume6
Issue number1
DOIs
StatePublished - 1 Jan 1996

Keywords

  • Lithium
  • Phorbol ester
  • Protein kinase C
  • Rat behavior

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