Phorbol ester intracerebroventricularly induces a behavioral hypoactivity that is not affected by chronic or acute lithium

Y. Patishi; Y. Bersudsky; R. H. Belmaker

doi:10.1016/0924-977X(95)00054-S

Phorbol ester intracerebroventricularly induces a behavioral hypoactivity that is not affected by chronic or acute lithium

Y. Patishi, Y. Bersudsky, R. H. Belmaker

Research output: Contribution to journal › Article › peer-review

4 Scopus citations

Abstract

Chronic lithium treatment in rats has been reported to decrease protein kinase C α isozyme in hippocampal membranes. We gave phorbol ester, a protein kinase C activator, i.c.v. to rats treated with acute or chronic lithium. Low dose phorbol ester causes a marked hypoactivity and high dose phorbol ester causes a barrel rolling behavior, but no behavioral interactions with lithium treatment were observed.

Original language	English
Pages (from-to)	39-41
Number of pages	3
Journal	European Neuropsychopharmacology
Volume	6
Issue number	1
DOIs	https://doi.org/10.1016/0924-977X(95)00054-S
State	Published - 1 Jan 1996

Keywords

Lithium
Phorbol ester
Protein kinase C
Rat behavior

ASJC Scopus subject areas

Pharmacology
Neurology
Clinical Neurology
Psychiatry and Mental health
Biological Psychiatry
Pharmacology (medical)

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10.1016/0924-977X(95)00054-S

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title = "Phorbol ester intracerebroventricularly induces a behavioral hypoactivity that is not affected by chronic or acute lithium",

abstract = "Chronic lithium treatment in rats has been reported to decrease protein kinase C α isozyme in hippocampal membranes. We gave phorbol ester, a protein kinase C activator, i.c.v. to rats treated with acute or chronic lithium. Low dose phorbol ester causes a marked hypoactivity and high dose phorbol ester causes a barrel rolling behavior, but no behavioral interactions with lithium treatment were observed.",

keywords = "Lithium, Phorbol ester, Protein kinase C, Rat behavior",

author = "Y. Patishi and Y. Bersudsky and Belmaker, {R. H.}",

note = "Funding Information: This work was supported by a grant from the German-Israel Foundation, Grant No. 1-245-098.02/92. The authors with to thank Dr. Richard S. Jope for stimulating comments on the manuscript.",

year = "1996",

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doi = "10.1016/0924-977X(95)00054-S",

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T1 - Phorbol ester intracerebroventricularly induces a behavioral hypoactivity that is not affected by chronic or acute lithium

AU - Patishi, Y.

AU - Bersudsky, Y.

AU - Belmaker, R. H.

N1 - Funding Information: This work was supported by a grant from the German-Israel Foundation, Grant No. 1-245-098.02/92. The authors with to thank Dr. Richard S. Jope for stimulating comments on the manuscript.

PY - 1996/1/1

Y1 - 1996/1/1

N2 - Chronic lithium treatment in rats has been reported to decrease protein kinase C α isozyme in hippocampal membranes. We gave phorbol ester, a protein kinase C activator, i.c.v. to rats treated with acute or chronic lithium. Low dose phorbol ester causes a marked hypoactivity and high dose phorbol ester causes a barrel rolling behavior, but no behavioral interactions with lithium treatment were observed.

AB - Chronic lithium treatment in rats has been reported to decrease protein kinase C α isozyme in hippocampal membranes. We gave phorbol ester, a protein kinase C activator, i.c.v. to rats treated with acute or chronic lithium. Low dose phorbol ester causes a marked hypoactivity and high dose phorbol ester causes a barrel rolling behavior, but no behavioral interactions with lithium treatment were observed.

KW - Lithium

KW - Phorbol ester

KW - Protein kinase C

KW - Rat behavior

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U2 - 10.1016/0924-977X(95)00054-S

DO - 10.1016/0924-977X(95)00054-S

M3 - Article

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SP - 39

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JO - European Neuropsychopharmacology

JF - European Neuropsychopharmacology

IS - 1

ER -

Phorbol ester intracerebroventricularly induces a behavioral hypoactivity that is not affected by chronic or acute lithium

Abstract

Keywords

ASJC Scopus subject areas

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