Photo-targeted nanoparticles

Tal Dvir; Matthew R. Banghart; Brian P. Timko; Robert Langer; Daniel S. Kohane

doi:10.1021/nl903411s

Photo-targeted nanoparticles

Tal Dvir
, Matthew R. Banghart
, Brian P. Timko
, Robert Langer
, Daniel S. Kohane

Research output: Contribution to journal › Article › peer-review

128 Scopus citations

Abstract

We report a novel and simple proof-of-concept of a nanoparticulate system that targets any tissue selectively upon illumination. Nanoparticles were covalently functionalized with the amino acid sequence YIGSR, which adheres to the β1 integrins present on most cell surfaces. This peptide was masked with a caging group, rendering it biologically inert. Illumination with UV light released the caging group from the YIGSR, allowing binding to cells.

Original language	English
Pages (from-to)	250-254
Number of pages	5
Journal	Nano Letters
Volume	10
Issue number	1
DOIs	https://doi.org/10.1021/nl903411s
State	Published - 13 Jan 2010
Externally published	Yes

Keywords

Caging group
Cell targeting
Drug delivery
Light
Nanoparticles

ASJC Scopus subject areas

Bioengineering
General Chemistry
General Materials Science
Condensed Matter Physics
Mechanical Engineering

Access to Document

10.1021/nl903411s

Cite this

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title = "Photo-targeted nanoparticles",

abstract = "We report a novel and simple proof-of-concept of a nanoparticulate system that targets any tissue selectively upon illumination. Nanoparticles were covalently functionalized with the amino acid sequence YIGSR, which adheres to the β1 integrins present on most cell surfaces. This peptide was masked with a caging group, rendering it biologically inert. Illumination with UV light released the caging group from the YIGSR, allowing binding to cells.",

keywords = "Caging group, Cell targeting, Drug delivery, Light, Nanoparticles",

author = "Tal Dvir and Banghart, \{Matthew R.\} and Timko, \{Brian P.\} and Robert Langer and Kohane, \{Daniel S.\}",

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AU - Dvir, Tal

AU - Banghart, Matthew R.

AU - Timko, Brian P.

AU - Langer, Robert

AU - Kohane, Daniel S.

PY - 2010/1/13

Y1 - 2010/1/13

N2 - We report a novel and simple proof-of-concept of a nanoparticulate system that targets any tissue selectively upon illumination. Nanoparticles were covalently functionalized with the amino acid sequence YIGSR, which adheres to the β1 integrins present on most cell surfaces. This peptide was masked with a caging group, rendering it biologically inert. Illumination with UV light released the caging group from the YIGSR, allowing binding to cells.

AB - We report a novel and simple proof-of-concept of a nanoparticulate system that targets any tissue selectively upon illumination. Nanoparticles were covalently functionalized with the amino acid sequence YIGSR, which adheres to the β1 integrins present on most cell surfaces. This peptide was masked with a caging group, rendering it biologically inert. Illumination with UV light released the caging group from the YIGSR, allowing binding to cells.

KW - Caging group

KW - Cell targeting

KW - Drug delivery

KW - Light

KW - Nanoparticles

UR - https://www.scopus.com/pages/publications/74849088269

U2 - 10.1021/nl903411s

DO - 10.1021/nl903411s

M3 - Article

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JO - Nano Letters

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Photo-targeted nanoparticles

Abstract

Keywords

ASJC Scopus subject areas

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