Photon activation therapy and brachytherapy

Brenda H. Laster; Dabney W. Dixon; Sara Novick; Jon P. Feldman; Veronique Seror; Zvi I. Goldbart; John A. Kalef-Ezra

doi:10.1016/j.brachy.2008.12.008

Photon activation therapy and brachytherapy

Brenda H. Laster, Dabney W. Dixon, Sara Novick, Jon P. Feldman, Veronique Seror, Zvi I. Goldbart, John A. Kalef-Ezra

Unit of Nuclear Engineering

Research output: Contribution to journal › Article › peer-review

8 Scopus citations

Abstract

Purpose: In photon activation therapy (PAT), energy deposition at critical sites within a tumor can be increased by complexing the DNA with higher Z atoms, and provoking the emission of Auger electrons after inducing a photoelectric effect. This in vivo study evaluates the hypothesis using X-rays from palladium-103 seeds to excite the L-edge of platinum (Pt) atoms bound to the DNA of cancerous cells. Methods and Materials: Pt (II) tetrakis(N-methyl-4-pyridyl) porphyrin chloride was used to locate Pt atoms adjacent to the DNA of the KHJJ murine mammary carcinoma; a 2.3-mCi palladium-103 seed was implanted in the tumor. Results: The tumor periphery received subtherapeutic doses. The rate of tumor growth in mice treated with PAT was slower than in mice treated with brachytherapy only. Conclusions: The tumor growth delay for PAT-treated mice is attributed to Auger emission from Pt atoms that produced substantial local damage. However, other co-existing mechanisms cannot be ruled out.

Original language	English
Pages (from-to)	324-330
Number of pages	7
Journal	Brachytherapy
Volume	8
Issue number	3
DOIs	https://doi.org/10.1016/j.brachy.2008.12.008
State	Published - 1 Jul 2009

Keywords

Auger electrons
Brachytherapy
Cancer
L-absorption edge
Photoelectric absorption
Photoelectric effect
Platinum
Porphyrin
Radiation
TMPyP4

ASJC Scopus subject areas

Oncology
Radiology Nuclear Medicine and imaging

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.1016/j.brachy.2008.12.008

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title = "Photon activation therapy and brachytherapy",

abstract = "Purpose: In photon activation therapy (PAT), energy deposition at critical sites within a tumor can be increased by complexing the DNA with higher Z atoms, and provoking the emission of Auger electrons after inducing a photoelectric effect. This in vivo study evaluates the hypothesis using X-rays from palladium-103 seeds to excite the L-edge of platinum (Pt) atoms bound to the DNA of cancerous cells. Methods and Materials: Pt (II) tetrakis(N-methyl-4-pyridyl) porphyrin chloride was used to locate Pt atoms adjacent to the DNA of the KHJJ murine mammary carcinoma; a 2.3-mCi palladium-103 seed was implanted in the tumor. Results: The tumor periphery received subtherapeutic doses. The rate of tumor growth in mice treated with PAT was slower than in mice treated with brachytherapy only. Conclusions: The tumor growth delay for PAT-treated mice is attributed to Auger emission from Pt atoms that produced substantial local damage. However, other co-existing mechanisms cannot be ruled out.",

keywords = "Auger electrons, Brachytherapy, Cancer, L-absorption edge, Photoelectric absorption, Photoelectric effect, Platinum, Porphyrin, Radiation, TMPyP4",

author = "Laster, {Brenda H.} and Dixon, {Dabney W.} and Sara Novick and Feldman, {Jon P.} and Veronique Seror and Goldbart, {Zvi I.} and Kalef-Ezra, {John A.}",

note = "Funding Information: This study was supported by the Israel Ministry of Science and Industry (BHL), the United States National Institutes of Health (AI45883, DWD), the Phyllis Tarlow Memorial Fund (BL), and the US-Israel Binational Foundation (BL and DWD). The cross-cultural program between Greece and Israel supported a trip of JK-E to Israel. The authors thank Ms. Anila Gill for technical assistance and Prof. Arie Dubi for valuable advice with statistics , as well as Rafi Srebro for his assistance in assuring the radiation safety aspects of the experiments.",

year = "2009",

month = jul,

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doi = "10.1016/j.brachy.2008.12.008",

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journal = "Brachytherapy",

issn = "1538-4721",

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T1 - Photon activation therapy and brachytherapy

AU - Laster, Brenda H.

AU - Dixon, Dabney W.

AU - Novick, Sara

AU - Feldman, Jon P.

AU - Seror, Veronique

AU - Goldbart, Zvi I.

AU - Kalef-Ezra, John A.

N1 - Funding Information: This study was supported by the Israel Ministry of Science and Industry (BHL), the United States National Institutes of Health (AI45883, DWD), the Phyllis Tarlow Memorial Fund (BL), and the US-Israel Binational Foundation (BL and DWD). The cross-cultural program between Greece and Israel supported a trip of JK-E to Israel. The authors thank Ms. Anila Gill for technical assistance and Prof. Arie Dubi for valuable advice with statistics , as well as Rafi Srebro for his assistance in assuring the radiation safety aspects of the experiments.

PY - 2009/7/1

Y1 - 2009/7/1

N2 - Purpose: In photon activation therapy (PAT), energy deposition at critical sites within a tumor can be increased by complexing the DNA with higher Z atoms, and provoking the emission of Auger electrons after inducing a photoelectric effect. This in vivo study evaluates the hypothesis using X-rays from palladium-103 seeds to excite the L-edge of platinum (Pt) atoms bound to the DNA of cancerous cells. Methods and Materials: Pt (II) tetrakis(N-methyl-4-pyridyl) porphyrin chloride was used to locate Pt atoms adjacent to the DNA of the KHJJ murine mammary carcinoma; a 2.3-mCi palladium-103 seed was implanted in the tumor. Results: The tumor periphery received subtherapeutic doses. The rate of tumor growth in mice treated with PAT was slower than in mice treated with brachytherapy only. Conclusions: The tumor growth delay for PAT-treated mice is attributed to Auger emission from Pt atoms that produced substantial local damage. However, other co-existing mechanisms cannot be ruled out.

AB - Purpose: In photon activation therapy (PAT), energy deposition at critical sites within a tumor can be increased by complexing the DNA with higher Z atoms, and provoking the emission of Auger electrons after inducing a photoelectric effect. This in vivo study evaluates the hypothesis using X-rays from palladium-103 seeds to excite the L-edge of platinum (Pt) atoms bound to the DNA of cancerous cells. Methods and Materials: Pt (II) tetrakis(N-methyl-4-pyridyl) porphyrin chloride was used to locate Pt atoms adjacent to the DNA of the KHJJ murine mammary carcinoma; a 2.3-mCi palladium-103 seed was implanted in the tumor. Results: The tumor periphery received subtherapeutic doses. The rate of tumor growth in mice treated with PAT was slower than in mice treated with brachytherapy only. Conclusions: The tumor growth delay for PAT-treated mice is attributed to Auger emission from Pt atoms that produced substantial local damage. However, other co-existing mechanisms cannot be ruled out.

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KW - Brachytherapy

KW - Cancer

KW - L-absorption edge

KW - Photoelectric absorption

KW - Photoelectric effect

KW - Platinum

KW - Porphyrin

KW - Radiation

KW - TMPyP4

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SN - 1538-4721

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EP - 330

JO - Brachytherapy

JF - Brachytherapy

IS - 3

ER -

Photon activation therapy and brachytherapy

Abstract

Keywords

ASJC Scopus subject areas

UN SDGs

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