Abstract
The present invention provides a photoreactive reagent that binds specifical ly to Ca2+-binding proteins, links to them covalently after photo-activation, a nd labels them. The novel reagent enables the characterization, purification, inhibition and screening of Ca2+-binding proteins, as well as the preparatio n of a new affinity chromatography matrix and a new protein biosensor. The invention also relates to the use of the reagent in inhibiting apoptosis and necrosis and in diagnosing a disorder associated with a defect in the functi on of a Ca2+-binding protein, and in the preparation of a medicament for treati ng such disorders.
| Original language | English |
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| Patent number | CA2556054 |
| IPC | C12N 11/ 14 A I |
| Priority date | 17/02/05 |
| State | Published - 1 Sep 2005 |