Abstract
The present invention provides a photoreactive reagent that
binds specifically to Ca"-binding proteins, links to them
covalently after photo-activation, and labels them. The novel
reagent enables the characterization, purification, inhibition
and screening of Ca'-binding proteins, as well as the prepa
ration of a new affinity chromatography matrix and a new
protein biosensor. The invention also relates to the use of the
reagent in inhibitingapoptosis and necrosis and in diagnosing
a disorder associated with a defect in the function of a Ca"-
binding protein, and in the preparation of a medicament for
treating Such disorders.
binds specifically to Ca"-binding proteins, links to them
covalently after photo-activation, and labels them. The novel
reagent enables the characterization, purification, inhibition
and screening of Ca'-binding proteins, as well as the prepa
ration of a new affinity chromatography matrix and a new
protein biosensor. The invention also relates to the use of the
reagent in inhibitingapoptosis and necrosis and in diagnosing
a disorder associated with a defect in the function of a Ca"-
binding protein, and in the preparation of a medicament for
treating Such disorders.
| Original language | English |
|---|---|
| Patent number | US 8,034,314 B2 |
| State | Published - 1 Oct 2011 |