Photoreactive compound specifically binding to calcium binding proteins

Varda Shoshan-Bar-Matz (Inventor), Adrian Israelson (Inventor)

Research output: Patent


The present invention provides a photoreactive reagent that
binds specifically to Ca"-binding proteins, links to them
covalently after photo-activation, and labels them. The novel
reagent enables the characterization, purification, inhibition
and screening of Ca'-binding proteins, as well as the prepa
ration of a new affinity chromatography matrix and a new
protein biosensor. The invention also relates to the use of the
reagent in inhibitingapoptosis and necrosis and in diagnosing
a disorder associated with a defect in the function of a Ca"-
binding protein, and in the preparation of a medicament for
treating Such disorders.
Original languageEnglish GB
Patent numberUS 8,034,314 B2
StatePublished - 1 Oct 2011


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