Photoresponsive crosslinked hyperbranched polyglycerols as smart nanocarriers for guest binding and controlled release

Ewelina Burakowska, Steven C. Zimmerman, Rainer Haag

Research output: Contribution to journalArticlepeer-review

54 Scopus citations

Abstract

A convenient methodology for the synthesis of photolabile crosslinked hyperbranched polyglycerol nanocapsules is presented. These nanocarriers selectively and efficiently bind ionic guest molecules. The stability of the host-guest complexes formed depends on the counterion of the guest molecules. Moreover, the control over guest binding can be achieved by modification of the polymer building blocks, in particular the outer shell. In addition, photo-triggered degradation of the nanocarrier leads to efficient release of encapsulated guest molecules. This approach, using photolabile dendritic nanocarriers to bind and release guest molecules, is of particular relevance for biomedical applications where selective guest binding and controlled release are crucial.

Original languageEnglish
Pages (from-to)2199-2204
Number of pages6
JournalSmall
Volume5
Issue number19
DOIs
StatePublished - 16 Oct 2009
Externally publishedYes

Keywords

  • Dendrimers
  • Encapsulation
  • Hyperbranched polymers
  • Nanocarriers
  • Supramolecular chemistry

ASJC Scopus subject areas

  • Engineering (miscellaneous)
  • General Chemistry
  • General Materials Science
  • Biotechnology
  • Biomaterials

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