Photothermally induced delayed tissue death

Jeffrey M. Gordon; Ruthy Shaco-Levy; Daniel Feuermann; Mahmoud Huleihil; Solly Mizrahi

doi:10.1117/1.2210948

Photothermally induced delayed tissue death

Jeffrey M. Gordon, Ruthy Shaco-Levy, Daniel Feuermann, Mahmoud Huleihil, Solly Mizrahi

Research output: Contribution to journal › Article › peer-review

4 Scopus citations

Abstract

We report pronounced delayed tissue death in photothermal surgery performed on the livers of live healthy rats with highly concentrated sunlight (ultrabright noncoherent light). Exposure times and power levels were selected to produce immediate necroses of the order of hundreds of cubic millimeters. Pathology reveals that lesion volumes increase by up to a factor of 5 within approximately 24 h after surgery, and then stabilize. Islands of viable cells can persist within damaged tissue, in the immediate vicinity of blood vessels, but also necrose within about 48 h.

Original language	English
Article number	030504
Journal	Journal of Biomedical Optics
Volume	11
Issue number	3
DOIs	https://doi.org/10.1117/1.2210948
State	Published - 1 May 2006

Keywords

Necrosis
Photothermal
Solar
Surgery

ASJC Scopus subject areas

Electronic, Optical and Magnetic Materials
Biomaterials
Atomic and Molecular Physics, and Optics
Biomedical Engineering

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10.1117/1.2210948

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title = "Photothermally induced delayed tissue death",

abstract = "We report pronounced delayed tissue death in photothermal surgery performed on the livers of live healthy rats with highly concentrated sunlight (ultrabright noncoherent light). Exposure times and power levels were selected to produce immediate necroses of the order of hundreds of cubic millimeters. Pathology reveals that lesion volumes increase by up to a factor of 5 within approximately 24 h after surgery, and then stabilize. Islands of viable cells can persist within damaged tissue, in the immediate vicinity of blood vessels, but also necrose within about 48 h.",

keywords = "Necrosis, Photothermal, Solar, Surgery",

author = "Gordon, {Jeffrey M.} and Ruthy Shaco-Levy and Daniel Feuermann and Mahmoud Huleihil and Solly Mizrahi",

note = "Funding Information: This work was supported by a grant from the Rita Altura Foundation, Los Angeles, CA. We are grateful to Rafi Itah for surgical assistance, and thank Yona Lichtenfeld and Lubov Stefanovsky for technical assistance in pathology slide preparation. This study was approved by the Institutional Animal Care and Use Committee of the Soroka Medical Center, Ben-Gurion University, Beersheva, Israel, and the surgeon (S.M.) underwent the health protection program for handling research animals.",

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AU - Shaco-Levy, Ruthy

AU - Feuermann, Daniel

AU - Huleihil, Mahmoud

AU - Mizrahi, Solly

N1 - Funding Information: This work was supported by a grant from the Rita Altura Foundation, Los Angeles, CA. We are grateful to Rafi Itah for surgical assistance, and thank Yona Lichtenfeld and Lubov Stefanovsky for technical assistance in pathology slide preparation. This study was approved by the Institutional Animal Care and Use Committee of the Soroka Medical Center, Ben-Gurion University, Beersheva, Israel, and the surgeon (S.M.) underwent the health protection program for handling research animals.

PY - 2006/5/1

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N2 - We report pronounced delayed tissue death in photothermal surgery performed on the livers of live healthy rats with highly concentrated sunlight (ultrabright noncoherent light). Exposure times and power levels were selected to produce immediate necroses of the order of hundreds of cubic millimeters. Pathology reveals that lesion volumes increase by up to a factor of 5 within approximately 24 h after surgery, and then stabilize. Islands of viable cells can persist within damaged tissue, in the immediate vicinity of blood vessels, but also necrose within about 48 h.

AB - We report pronounced delayed tissue death in photothermal surgery performed on the livers of live healthy rats with highly concentrated sunlight (ultrabright noncoherent light). Exposure times and power levels were selected to produce immediate necroses of the order of hundreds of cubic millimeters. Pathology reveals that lesion volumes increase by up to a factor of 5 within approximately 24 h after surgery, and then stabilize. Islands of viable cells can persist within damaged tissue, in the immediate vicinity of blood vessels, but also necrose within about 48 h.

KW - Necrosis

KW - Photothermal

KW - Solar

KW - Surgery

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Photothermally induced delayed tissue death

Abstract

Keywords

ASJC Scopus subject areas

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