Photothermally induced delayed tissue death

Jeffrey M. Gordon, Ruthy Shaco-Levy, Daniel Feuermann, Mahmoud Huleihil, Solly Mizrahi

    Research output: Contribution to journalArticlepeer-review

    5 Scopus citations

    Abstract

    We report pronounced delayed tissue death in photothermal surgery performed on the livers of live healthy rats with highly concentrated sunlight (ultrabright noncoherent light). Exposure times and power levels were selected to produce immediate necroses of the order of hundreds of cubic millimeters. Pathology reveals that lesion volumes increase by up to a factor of 5 within approximately 24 h after surgery, and then stabilize. Islands of viable cells can persist within damaged tissue, in the immediate vicinity of blood vessels, but also necrose within about 48 h.

    Original languageEnglish
    Article number030504
    JournalJournal of Biomedical Optics
    Volume11
    Issue number3
    DOIs
    StatePublished - 1 May 2006

    Keywords

    • Necrosis
    • Photothermal
    • Solar
    • Surgery

    ASJC Scopus subject areas

    • Electronic, Optical and Magnetic Materials
    • Biomaterials
    • Atomic and Molecular Physics, and Optics
    • Biomedical Engineering

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