Photothermally induced delayed tissue death

Jeffrey M. Gordon, Ruthy Shaco-Levy, Daniel Feuermann, Mahmoud Huleihil, Solly Mizrahi

Research output: Contribution to journalArticlepeer-review

5 Scopus citations

Abstract

We report pronounced delayed tissue death in photothermal surgery performed on the livers of live healthy rats with highly concentrated sunlight (ultrabright noncoherent light). Exposure times and power levels were selected to produce immediate necroses of the order of hundreds of cubic millimeters. Pathology reveals that lesion volumes increase by up to a factor of 5 within approximately 24 h after surgery, and then stabilize. Islands of viable cells can persist within damaged tissue, in the immediate vicinity of blood vessels, but also necrose within about 48 h.

Original languageEnglish
Article number030504
JournalJournal of Biomedical Optics
Volume11
Issue number3
DOIs
StatePublished - 1 May 2006

Keywords

  • Necrosis
  • Photothermal
  • Solar
  • Surgery

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