Physical and biological doses produced from neutron capture in a ²³⁵U foil

As a follow-on study to the feasibility of neutron capture therapy (NCT) with ²³⁵U brachytherapy seeds, physical doses were calculated and measured for the radiation from a ²³⁵U foil in a lucite phantom which was irradiated at the epithermal neutron irradiation port of the Brookhaven Medical Research Reactor. In addition, cell survival experiments were performed to obtain the relative biological effectiveness (RBE) for the neutron part of the radiation. The calculated absorbed doses agree with the measured ones. From cell survival experiments, it is deduced that the fission neutrons from the ²³⁵U foil have a RBE of 3.0 while the fast neutrons in the beam have a RBE of 3.8. Also observed is that, with the cells 7 mm from the foil, a significant amount of absorbed dose comes from the 13 rays of ²³⁵U fission events. This absorbed dose from f3 rays is a significant addition to the therapeutic dose. Due to the limited ranges of/3 rays in tissue, this absorbed dose is restricted to the vicinity of the foil. This is the first demonstration of (3 rays as part of NCT.