Physical exosome:exosome interactions

Elie Beit-Yannai, Saray Tabak, W. Daniel Stamer

Research output: Contribution to journalArticlepeer-review

59 Scopus citations

Abstract

Exosomes are extracellular nanovesicles that mediate a number of cellular processes, including intracellular signalling. There are many published examples of exosome–exosome dimers; however, their relevance has not been explored. Here, we propose that cells release exosomes to physically interact with incoming exosomes, forming dimers that we hypothesize attenuate incoming exosome-mediated signalling. We discuss experiments to test this hypothesis and potential relevance in health and disease.

Original languageEnglish
Pages (from-to)2001-2006
Number of pages6
JournalJournal of Cellular and Molecular Medicine
Volume22
Issue number3
DOIs
StatePublished - 1 Mar 2018

Keywords

  • exosome
  • hypothesis
  • physical interaction
  • signalling
  • zeta potential

ASJC Scopus subject areas

  • Molecular Medicine
  • Cell Biology

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