Physiological variables and mitochondrial-related genotypes of an athlete who excels in both short and long-distance running

Nir Eynon; Ruth Birk; Yoav Meckel; Alejandro Lucia; Dan Nemet; Alon Eliakim

doi:10.1016/j.mito.2011.05.009

Physiological variables and mitochondrial-related genotypes of an athlete who excels in both short and long-distance running

Nir Eynon, Ruth Birk, Yoav Meckel, Alejandro Lucia, Dan Nemet, Alon Eliakim

Research output: Contribution to journal › Article › peer-review

11 Scopus citations

Abstract

We report the athletic, physiological and mitochondrial-related genomic data of an Israeli endurance runner. He is holding the Israeli record in 10,000, 5000, 1500 and 800. m run, along with being one of the best Israeli 400. m runners. We tested the ACTN3 R577X, and six polymorphisms in the PPARGC1A-NRF-TFAM pathway genes. The case athlete was heterozygous for the ACTN3 R577X variation and had five out of six 'endurance-oriented' genotypes, scoring significantly high in endurance 'optimal' genotype profile. In conclusion, we suggest that the case athlete is favoured by polygenic profile that is more suitable for mitochondrial biogenesis, regardless of his good phenotypic accomplishments in short-term running events.

Original language	English
Pages (from-to)	774-777
Number of pages	4
Journal	Mitochondrion
Volume	11
Issue number	5
DOIs	https://doi.org/10.1016/j.mito.2011.05.009
State	Published - 1 Sep 2011
Externally published	Yes

Keywords

Endurance athlete
Genetics
Mitochondria

ASJC Scopus subject areas

Molecular Medicine
Molecular Biology
Cell Biology

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10.1016/j.mito.2011.05.009

Cite this

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title = "Physiological variables and mitochondrial-related genotypes of an athlete who excels in both short and long-distance running",

abstract = "We report the athletic, physiological and mitochondrial-related genomic data of an Israeli endurance runner. He is holding the Israeli record in 10,000, 5000, 1500 and 800. m run, along with being one of the best Israeli 400. m runners. We tested the ACTN3 R577X, and six polymorphisms in the PPARGC1A-NRF-TFAM pathway genes. The case athlete was heterozygous for the ACTN3 R577X variation and had five out of six 'endurance-oriented' genotypes, scoring significantly high in endurance 'optimal' genotype profile. In conclusion, we suggest that the case athlete is favoured by polygenic profile that is more suitable for mitochondrial biogenesis, regardless of his good phenotypic accomplishments in short-term running events.",

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T1 - Physiological variables and mitochondrial-related genotypes of an athlete who excels in both short and long-distance running

AU - Eynon, Nir

AU - Birk, Ruth

AU - Meckel, Yoav

AU - Lucia, Alejandro

AU - Nemet, Dan

AU - Eliakim, Alon

PY - 2011/9/1

Y1 - 2011/9/1

N2 - We report the athletic, physiological and mitochondrial-related genomic data of an Israeli endurance runner. He is holding the Israeli record in 10,000, 5000, 1500 and 800. m run, along with being one of the best Israeli 400. m runners. We tested the ACTN3 R577X, and six polymorphisms in the PPARGC1A-NRF-TFAM pathway genes. The case athlete was heterozygous for the ACTN3 R577X variation and had five out of six 'endurance-oriented' genotypes, scoring significantly high in endurance 'optimal' genotype profile. In conclusion, we suggest that the case athlete is favoured by polygenic profile that is more suitable for mitochondrial biogenesis, regardless of his good phenotypic accomplishments in short-term running events.

AB - We report the athletic, physiological and mitochondrial-related genomic data of an Israeli endurance runner. He is holding the Israeli record in 10,000, 5000, 1500 and 800. m run, along with being one of the best Israeli 400. m runners. We tested the ACTN3 R577X, and six polymorphisms in the PPARGC1A-NRF-TFAM pathway genes. The case athlete was heterozygous for the ACTN3 R577X variation and had five out of six 'endurance-oriented' genotypes, scoring significantly high in endurance 'optimal' genotype profile. In conclusion, we suggest that the case athlete is favoured by polygenic profile that is more suitable for mitochondrial biogenesis, regardless of his good phenotypic accomplishments in short-term running events.

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KW - Genetics

KW - Mitochondria

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Physiological variables and mitochondrial-related genotypes of an athlete who excels in both short and long-distance running

Abstract

Keywords

ASJC Scopus subject areas

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