TY - JOUR
T1 - Phytochemical analysis and evaluation of antioxidant and free radical scavenging activity of withania somnifera root
AU - Chaudhuri, Dipankar
AU - Ghate, Nikhil Baban
AU - Sarkar, Rhitajit
AU - Mandal, Nripendranath
N1 - Funding Information:
The authors declare the following financial interests/personal relationships which may be considered as potential competing interests: [Drs. Zimmerman, Nowalk and Lin report grant funding from Sanofi Pasteur and Merck & Co., Inc. Dr. Zimmerman reports grant funding from Pfizer. Dr. Alcorn has grant funding from MedImmune, LLC for unrelated research. Dr. Moehling and Mr. Susick have had research funding from Sanofi Pasteur. Dr. Martin has research funding from Novus Therapeutics, MedImmune, GSK and Merck & CO, Inc. The other authors have no conflicts to report.].
Funding Information:
This work was supported by the Centers for Disease Control and Prevention (CDC) [5U01IP001035-02] and by National Institutes of Health (NIH) [UL1TR001857]. This work represents the views of the authors and not the CDC or NIH. Fluzone was provided by Sanofi Pasteur which had no other role in the study. No other funding was received.
PY - 2012/11/1
Y1 - 2012/11/1
N2 - Withania somnifera, also known as 'Ashwagandha', is an important medicinal plant that has been used in Ayurvedic and indigenous medicine for over 3,000 years. In view of its varied therapeutic potential, it has also been the subject of considerable modern scientific attention. The present study was performed to evaluate the phytochemicals and in vitro antioxidant activity of 70% methanolic extract of W. somnifera roots. The extract was used to determine the antioxidant potential using different tests including total antioxidant activity; efficiencies for scavenging of hydroxyl, superoxide, nitric oxide, singlet oxygen radicals, hypochlorous acid and inhibition of lipid peroxidation. The results obtained indicate that although W. somnifera has been widely used for centuries as immunostimulants in different ailments including neurodegenerative disorders, the 70% methanolic extract of the same also has possibility as an antioxidant and free radical scavenging agent.
AB - Withania somnifera, also known as 'Ashwagandha', is an important medicinal plant that has been used in Ayurvedic and indigenous medicine for over 3,000 years. In view of its varied therapeutic potential, it has also been the subject of considerable modern scientific attention. The present study was performed to evaluate the phytochemicals and in vitro antioxidant activity of 70% methanolic extract of W. somnifera roots. The extract was used to determine the antioxidant potential using different tests including total antioxidant activity; efficiencies for scavenging of hydroxyl, superoxide, nitric oxide, singlet oxygen radicals, hypochlorous acid and inhibition of lipid peroxidation. The results obtained indicate that although W. somnifera has been widely used for centuries as immunostimulants in different ailments including neurodegenerative disorders, the 70% methanolic extract of the same also has possibility as an antioxidant and free radical scavenging agent.
KW - Phytochemical screening
KW - Reactive oxygen species
KW - Reducing power
UR - http://www.scopus.com/inward/record.url?scp=84874745691&partnerID=8YFLogxK
M3 - Article
AN - SCOPUS:84874745691
SN - 0974-2441
VL - 5
SP - 193
EP - 199
JO - Asian Journal of Pharmaceutical and Clinical Research
JF - Asian Journal of Pharmaceutical and Clinical Research
IS - SUPPL.4
ER -