Phytocompound Mediated Blockage of Quorum Sensing Cascade in ESKAPE Pathogens

Sreejita Ghosh, Dibyajit Lahiri, Moupriya Nag, Ankita Dey, Soumya Pandit, Tanmay Sarkar, Siddhartha Pati, Zulhisyam Abdul Kari, Ahmad Razali Ishak, Hisham Atan Edinur, Rina Rani Ray

Research output: Contribution to journalReview articlepeer-review

21 Scopus citations

Abstract

Increased resistance of Enterococcus faecium, Staphylococcus aureus, Klebsiella pneumoniae, Acinetobacter baumannii, Pseudomonas aeruginosa, and Enterobacter sp. (ESKAPE) pathogens against various drugs has enhanced the urge for the development of alternate therapeutics. Quorum sensing (QS) is a density dependent cell-to-cell communication mechanism responsible for controlling pathogenicity with the regulation of gene expression. Thus, QS is considered a potential target for the development of newer anti-biofilm agents that do not depend on the utilization of antibiotics. Compounds with anti-QS effects are known as QS inhibitors (QSIs), and they can inhibit the QS mechanism that forms the major form in the development of bacterial pathogenesis. A diverse array of natural compounds provides a plethora of anti-QS effects. Over recent years, these natural compounds have gained importance as new strategies for combating the ESKAPE pathogens and inhibiting the genes involved in QS. Different pharmacognostical and pharmacological studies have been carried out so far for identification of novel drugs or for the discovery of their unique structures that may help in developing more effective anti-biofilm therapies. The main objective of this review is to discuss the various natural compounds, so far identified and their employed mechanisms in hindering the genes responsible for QS leading to bacterial pathogenesis.

Original languageEnglish
Article number61
JournalAntibiotics
Volume11
Issue number1
DOIs
StatePublished - 1 Jan 2022
Externally publishedYes

Keywords

  • Bacterial pathogenesis
  • ESKAPE pathogens
  • QS inhibitors
  • Quorum sensing

ASJC Scopus subject areas

  • Microbiology (medical)
  • Infectious Diseases
  • Pharmacology (medical)
  • Biochemistry
  • Pharmacology, Toxicology and Pharmaceutics (all)
  • Microbiology

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