PIDA-Catalysed oxidative C–C bond cleavage for the direct synthesis of benzoic acids and antibacterial studies of the amides derivatives

Swadhapriya Bhukta; Omkar S. Kamble; Rana Chatterjee; Rambabu Dandela

doi:10.1016/j.jics.2023.101095

PIDA-Catalysed oxidative C–C bond cleavage for the direct synthesis of benzoic acids and antibacterial studies of the amides derivatives

Swadhapriya Bhukta, Omkar S. Kamble, Rana Chatterjee, Rambabu Dandela

Research output: Contribution to journal › Article › peer-review

1 Scopus citations

Abstract

A hypervalent iodine, (diacetoxyiodo)benzene (PIDA) catalysed facile synthesis of benzoic acids has been developed from aromatic ketone through oxidative C–C bond cleavage. A series of aromatic ketones get converted to the corresponding aromatic acid via oxime intermediate. Additionally, we have also utilized the resulted benzoic acid for the amide compounds using drug intermediate and studied the antibacterial activities. The use of hypervalent iodine, milder reaction conditions, good to high yields, clean protocols, the biological application are the notable features of the method.

Original language	English
Article number	101095
Journal	Journal of the Indian Chemical Society
Volume	100
Issue number	10
DOIs	https://doi.org/10.1016/j.jics.2023.101095
State	Published - 1 Oct 2023
Externally published	Yes

Keywords

(Diacetoxyiodo)benzene
Amide synthesis
Antibacterial studies
Benzoic acids
C–C bond cleavage

ASJC Scopus subject areas

Drug Discovery
Physical and Theoretical Chemistry
Organic Chemistry
Inorganic Chemistry
Electrochemistry

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10.1016/j.jics.2023.101095

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title = "PIDA-Catalysed oxidative C–C bond cleavage for the direct synthesis of benzoic acids and antibacterial studies of the amides derivatives",

abstract = "A hypervalent iodine, (diacetoxyiodo)benzene (PIDA) catalysed facile synthesis of benzoic acids has been developed from aromatic ketone through oxidative C–C bond cleavage. A series of aromatic ketones get converted to the corresponding aromatic acid via oxime intermediate. Additionally, we have also utilized the resulted benzoic acid for the amide compounds using drug intermediate and studied the antibacterial activities. The use of hypervalent iodine, milder reaction conditions, good to high yields, clean protocols, the biological application are the notable features of the method.",

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author = "Swadhapriya Bhukta and Kamble, {Omkar S.} and Rana Chatterjee and Rambabu Dandela",

note = "Publisher Copyright: {\textcopyright} 2023 Indian Chemical Society",

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AU - Bhukta, Swadhapriya

AU - Kamble, Omkar S.

AU - Chatterjee, Rana

AU - Dandela, Rambabu

PY - 2023/10/1

Y1 - 2023/10/1

N2 - A hypervalent iodine, (diacetoxyiodo)benzene (PIDA) catalysed facile synthesis of benzoic acids has been developed from aromatic ketone through oxidative C–C bond cleavage. A series of aromatic ketones get converted to the corresponding aromatic acid via oxime intermediate. Additionally, we have also utilized the resulted benzoic acid for the amide compounds using drug intermediate and studied the antibacterial activities. The use of hypervalent iodine, milder reaction conditions, good to high yields, clean protocols, the biological application are the notable features of the method.

AB - A hypervalent iodine, (diacetoxyiodo)benzene (PIDA) catalysed facile synthesis of benzoic acids has been developed from aromatic ketone through oxidative C–C bond cleavage. A series of aromatic ketones get converted to the corresponding aromatic acid via oxime intermediate. Additionally, we have also utilized the resulted benzoic acid for the amide compounds using drug intermediate and studied the antibacterial activities. The use of hypervalent iodine, milder reaction conditions, good to high yields, clean protocols, the biological application are the notable features of the method.

KW - (Diacetoxyiodo)benzene

KW - Amide synthesis

KW - Antibacterial studies

KW - Benzoic acids

KW - C–C bond cleavage

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JO - Journal of the Indian Chemical Society

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ER -

PIDA-Catalysed oxidative C–C bond cleavage for the direct synthesis of benzoic acids and antibacterial studies of the amides derivatives

Abstract

Keywords

ASJC Scopus subject areas

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