Pituitary-adrenal activity and depletion of brain catecholamines after α-methyl-p-tyrosine administration

J. Kaplanski; W. Dorst; P. G. Smelik

doi:10.1016/0014-2999(72)90154-9

Pituitary-adrenal activity and depletion of brain catecholamines after α-methyl-p-tyrosine administration

J. Kaplanski, W. Dorst, P. G. Smelik

Research output: Contribution to journal › Article › peer-review

5 Scopus citations

Abstract

I.p. injection of 250 mg/kg of α-methyl-p-tyrosine (α-MT), into male rats, increased adrenocortical activity. In contrast, repeated administration of 50 mg/kg α-MT, did not activate the pituitary-adrenal system. However, both treatments induced a significant fall in brain catecholamine (CA) content. This datum questions a causal relationship between CA depletion in the brain and stimulation of ACTH secretion.

Original language	English
Pages (from-to)	238-240
Number of pages	3
Journal	European Journal of Pharmacology
Volume	20
Issue number	2
DOIs	https://doi.org/10.1016/0014-2999(72)90154-9
State	Published - 1 Jan 1972
Externally published	Yes

Keywords

Brain catecholamine
Pituitary-adrenal system
α-Methyl-p-tyrosine

ASJC Scopus subject areas

Pharmacology

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10.1016/0014-2999(72)90154-9

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title = "Pituitary-adrenal activity and depletion of brain catecholamines after α-methyl-p-tyrosine administration",

abstract = "I.p. injection of 250 mg/kg of α-methyl-p-tyrosine (α-MT), into male rats, increased adrenocortical activity. In contrast, repeated administration of 50 mg/kg α-MT, did not activate the pituitary-adrenal system. However, both treatments induced a significant fall in brain catecholamine (CA) content. This datum questions a causal relationship between CA depletion in the brain and stimulation of ACTH secretion.",

keywords = "Brain catecholamine, Pituitary-adrenal system, α-Methyl-p-tyrosine",

author = "J. Kaplanski and W. Dorst and Smelik, {P. G.}",

year = "1972",

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AU - Kaplanski, J.

AU - Dorst, W.

AU - Smelik, P. G.

PY - 1972/1/1

Y1 - 1972/1/1

N2 - I.p. injection of 250 mg/kg of α-methyl-p-tyrosine (α-MT), into male rats, increased adrenocortical activity. In contrast, repeated administration of 50 mg/kg α-MT, did not activate the pituitary-adrenal system. However, both treatments induced a significant fall in brain catecholamine (CA) content. This datum questions a causal relationship between CA depletion in the brain and stimulation of ACTH secretion.

AB - I.p. injection of 250 mg/kg of α-methyl-p-tyrosine (α-MT), into male rats, increased adrenocortical activity. In contrast, repeated administration of 50 mg/kg α-MT, did not activate the pituitary-adrenal system. However, both treatments induced a significant fall in brain catecholamine (CA) content. This datum questions a causal relationship between CA depletion in the brain and stimulation of ACTH secretion.

KW - Brain catecholamine

KW - Pituitary-adrenal system

KW - α-Methyl-p-tyrosine

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JF - European Journal of Pharmacology

IS - 2

ER -

Pituitary-adrenal activity and depletion of brain catecholamines after α-methyl-p-tyrosine administration

Abstract

Keywords

ASJC Scopus subject areas

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