Pituitary-adrenal activity and depletion of brain catecholamines after α-methyl-p-tyrosine administration

J. Kaplanski, W. Dorst, P. G. Smelik

Research output: Contribution to journalArticlepeer-review

5 Scopus citations

Abstract

I.p. injection of 250 mg/kg of α-methyl-p-tyrosine (α-MT), into male rats, increased adrenocortical activity. In contrast, repeated administration of 50 mg/kg α-MT, did not activate the pituitary-adrenal system. However, both treatments induced a significant fall in brain catecholamine (CA) content. This datum questions a causal relationship between CA depletion in the brain and stimulation of ACTH secretion.

Original languageEnglish
Pages (from-to)238-240
Number of pages3
JournalEuropean Journal of Pharmacology
Volume20
Issue number2
DOIs
StatePublished - 1 Jan 1972
Externally publishedYes

Keywords

  • Brain catecholamine
  • Pituitary-adrenal system
  • α-Methyl-p-tyrosine

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