I.p. injection of 250 mg/kg of α-methyl-p-tyrosine (α-MT), into male rats, increased adrenocortical activity. In contrast, repeated administration of 50 mg/kg α-MT, did not activate the pituitary-adrenal system. However, both treatments induced a significant fall in brain catecholamine (CA) content. This datum questions a causal relationship between CA depletion in the brain and stimulation of ACTH secretion.
- Brain catecholamine
- Pituitary-adrenal system