Placental pathologies associated with intra-uterine fetal growth restriction complicated with and without oligohydramnios

Liat Apel-Sarid, Amalia Levy, Gershon Holcberg, Eyal Sheiner

    Research output: Contribution to journalArticlepeer-review

    19 Scopus citations

    Abstract

    Purpose: To compare the placental pathologies and perinatal outcomes in fetal growth restriction (FGR) pregnancies with and without oligohydramnios. Methods: A retrospective cohort study, comparing placental findings in all singleton deliveries with FGR. Results: Macroscopic placental findings were available for 1,104 singleton FGR pregnancies. A total of 397 placentas were microscopically examined; of which 89 placentas were of FGR neonates who had oligohydramnios. No significant differences in placental vascular mal-perfusion were found between pregnancies with and without oligohydramnios (69.3 vs. 74.3%; P = 0.357). Likewise, no significant differences were noted between the groups regarding diffuse villous fibrosis (10.1 vs. 4.9%; P = 0.573), and amnion cell metaplasia (65.9 vs. 64.3%; P = 0.779). Cases of FGR complicated with oligohydramnios had significantly higher rates of perinatal mortality (9.9 vs. 5.9%; P = 0.028), preterm deliveries (34.9 ± 3.4 vs. 35.4 ± 3.1 weeks of pregnancy; P = 0.041), and lower birth weight (1,737 ± 542 vs. 1,845 ± 467 g; P = 0.002) compared to FGR without oligohydramnios. Conclusions: Oligohydramnios is a significant risk factor for adverse perinatal outcome in FGR pregnancies; nevertheless, no significant differences in placental pathologies were noted.

    Original languageEnglish
    Pages (from-to)549-552
    Number of pages4
    JournalArchives of Gynecology and Obstetrics
    Volume280
    Issue number4
    DOIs
    StatePublished - 1 Oct 2009

    Keywords

    • Fetal growth restriction
    • Oligohydramnios
    • Placenta
    • Vascular mal-perfusion

    ASJC Scopus subject areas

    • Obstetrics and Gynecology

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