Placental pathology in fetal thrombophilia

Ilana Ariel, Eyal Anteby, Yaron Hamani, Raymond W. Redline

    Research output: Contribution to journalArticlepeer-review

    64 Scopus citations

    Abstract

    The aim of this study was to test the hypothesis that placental vascular lesions of the fetal circulation are caused by fetal thrombophilic mutations. The study included 64 newborns of women with one or more of the following pregnancy complications: preeclampsia, placental abruption, and intrauterine growth restriction. The most prevalent inherited thrombophilias - factor V Leiden, factor II (prothrombin) G20210A, and homozygosity for methyltetrahydrofolate reductase C677T - were examined in maternal blood and fetal umbilical cord blood. One pathologist reviewed all of the slides for fetal vascular lesions. Associations between fetal thrombotic vasculopathy and fetal thrombophilia were tested for using Fisher's exact test; Z scores and gestational age were compared using the Student t-test. Fetal thrombophilic mutations were diagnosed in 19 of 64 newborns, 15 of whom had coexistent maternal thrombophilia. There was no statistical difference in the prevalence of thrombotic lesions of the fetal circulation between newborns with and without thrombophilia. The combination of maternal and fetal thrombophilia was also not associated with increased fetal vascular lesions. The results indicate that fetal thrombophilia alone, even in the context of maternal underperfusion, is not associated with fetal vascular lesions of the placenta, although it may represent an underlying risk factor for lesions triggered by other process(es).

    Original languageEnglish
    Pages (from-to)729-733
    Number of pages5
    JournalHuman Pathology
    Volume35
    Issue number6
    DOIs
    StatePublished - 1 Jun 2004

    Keywords

    • IUGR
    • MTHFR
    • PCR
    • fetal thrombotic vasculopathy
    • intrauterine growth restriction
    • methylenetetrahydrofolate reductase
    • placenta
    • polymerase chain reaction
    • thrombophilic mutations

    ASJC Scopus subject areas

    • Pathology and Forensic Medicine

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