The chemical marks that provide the major means by which epigenetics manifests its effect on chromatin structure and function have been discovered long ago almost along with the invention of the term epigenome by Conrad H. Waddington. However, it had to wait several decades before the connection between epigenetics and chemical modifications of DNA and histone proteins has been established. Many of the modifying enzymes responsible for the dynamic modifications of DNA and histones such as histone methyltransferases and histone demethylases have only recently been identified and molecularly characterized. This introductory chapter provides a historical view on epigenetics: when and how it has begun and where it is going.
|Name||Signaling and Communication in Plants|
- Cytosine Methylation
- Histone Protein
- Position Effect Variegation
- Ddm1 Mutant