Plasma cyclic AMP and cyclic GMP in childhood-onset psychoses

Meir Goldberg, Jocelyn Hattab, Daniel Meir, R. P. Ebstein, R. H. Belmaker

Research output: Contribution to journalArticlepeer-review

7 Scopus citations


Plasma cyclic AMP is a "second messenger" that may reflect levels of activity of important neurotransmitter receptors. Plasma cyclic AMP was measured in 18 patients with childhood autism, 7 patients with pervasive developmental disorder, and 12 age- and sex-matched healthy controls. Plasma cyclic AMP was significantly elevated by over 100% in both groups of patients with childhood-onset psychoses compared with controls. Plasma cyclic GMP, a nucleotide linked to different receptors, was not elevated, suggesting that the finding may be specific.

Original languageEnglish
Pages (from-to)159-164
Number of pages6
JournalJournal of Autism and Developmental Disorders
Issue number2
StatePublished - 1 Jun 1984
Externally publishedYes


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