Plasma selenium is positively related to performance in neurological tasks assessing coordination and motor speed

Avner Shahar, Kushang V. Patel, Richard D. Semba, Stefania Bandinelli, Danit R. Shahar, Louigi Ferrucci, Jack M. Guralnik

    Research output: Contribution to journalArticlepeer-review

    87 Scopus citations

    Abstract

    Parkinson's disease (PD) is a degenerative process affecting the striato nigral system (SN). Its etiology, although obscure, may involve oxidative damage. Selenium, an antioxidant, was shown to protect the SN in animal models. In the current study, we investigate the association between plasma selenium concentrations and the presence of "soft" neurological signs related to the SN. Plasma selenium concentration was assessed in participants of age ≥65 years in the InCHIANTI study, a population-based cohort study in Tuscany, Italy. PD was defined based on standard criteria. "Soft" neurological signs were ascertained by physical examination. A total of 1,012 participants were included. No association was found between the presence of PD and plasma selenium. There was, however, a strong association between plasma selenium and timed performance-based assessments. Lower levels of selenium were significantly associated with decreased performance in neurological tests of coordination among older adults. Prospective studies are needed to further investigate the effects of selenium on SN dysfunction.

    Original languageEnglish
    Pages (from-to)1909-1915
    Number of pages7
    JournalMovement Disorders
    Volume25
    Issue number12
    DOIs
    StatePublished - 15 Sep 2010

    Keywords

    • Antioxidants
    • Elderly
    • Parkinson's disease
    • Selenium
    • Trace elements

    ASJC Scopus subject areas

    • Neurology
    • Clinical Neurology

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