Plasmapheresis rapidly eliminates thyroid hormones from the circulation, but does not affect the speed of TSH recovery following prolonged suppression

Yair Liel, Natan Weksler

Research output: Contribution to journalArticlepeer-review

6 Scopus citations

Abstract

Objective: To report an attempt to shorten the preparation interval before radioactive iodine administration using plasmapheresis in a 77-year-old woman with a history of papillary thyroid carcinoma with local recurrence and lung metastases, in whom the administration of a high dose of radioactive iodine was intended as a desperate rescue procedure. Methods: The patient was initially started on cholestyramine. Two days later, plasmapheresis was performed. Results: Plasmapheresis rapidly decreased free tri-iodothyronine (FT 3) and free thyroxine (FT4). Serum FT4 subsequently remained low, while FT3 recovered the next day. Thyroid-stimulating hormone (TSH) reached 25 mlU/l in 14 days, which is within the time frame required to reach the target TSH level by withdrawing levothyroxine alone. Conclusion: Plasmapheresis is very effective in eliminating thyroid hormones from the circulation. However, it does not seem to accelerate thyrotroph recovery to a considerable extent after prolonged suppression.

Original languageEnglish
Pages (from-to)252-254
Number of pages3
JournalHormone Research
Volume60
Issue number5
DOIs
StatePublished - 8 Dec 2003
Externally publishedYes

Keywords

  • Plasmapheresis
  • Thyroid hormones
  • Thyroid neoplasia
  • Thyroid-stimulating hormone

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