Plasmodium falciparum: Evidence for a DNA methylation pattern

Yaakov Pollack, Nina Kogan, Jacob Golenser

Research output: Contribution to journalArticlepeer-review

29 Scopus citations

Abstract

The methylation status of the adenine and cytosine residues in the genome of Plasmodium falciparum was studied using restriction enzymes exhibiting differential activity dependent on the methylation state of these residues in their recognition site. The gene coding for the enzyme dihydrofolate reductase-thymidylate synthase was studied for that purpose. No methylated adenine residues were observed in this gene in four strains tested. However, partial methylation of cytosine residues was observed in all strains. This methylation occurred at a specific site of the gene and was of the eukaryotic type, namely at a CpG sequence.

Original languageEnglish
Pages (from-to)339-344
Number of pages6
JournalExperimental Parasitology
Volume72
Issue number4
DOIs
StatePublished - 1 Jan 1991

Keywords

  • 5-Methylcytosine
  • 6-Methyladenine
  • DHFR-TS gene
  • DNA methylation
  • Plasmodium falciparum

ASJC Scopus subject areas

  • Parasitology
  • Immunology
  • Infectious Diseases

Fingerprint

Dive into the research topics of 'Plasmodium falciparum: Evidence for a DNA methylation pattern'. Together they form a unique fingerprint.

Cite this