Plasmodium falciparum: In vitro induction of resistance to aminopterin

J. Golenser, D. Casuto, Y. Pollack

Research output: Contribution to journalArticlepeer-review

18 Scopus citations


Plasmodium falciparum parasites were grown on microplates in the presence of aminopterin. The FCR-8 strain was more sensitive to aminopterin than a Richards strain and died within 1 week of treatment. A few parasites of the Richards strain survived treatment and developed normal parasitemias. This strain was resistant to aminopterin at concentrations not higher than those used for its selection. Removal of aminopterin did not affect the growth of the resistant variant, showing that it was not aminopterin dependent. Aminopterin affected the sensitive parasites by interfering with nucleic acid synthesis, whereas protein synthesis was not impaired. Gametocytogenesis was unaffected by aminopterin.

Original languageEnglish
Pages (from-to)371-377
Number of pages7
JournalExperimental Parasitology
Issue number3
StatePublished - 1 Jan 1981
Externally publishedYes


  • Aminopterin
  • Culture, in vitro
  • Drug resistance
  • Hypoxanthine incorporation
  • Isoleucine incorporation
  • Malaria
  • Plasmodium falciparum
  • Primate
  • Protozoa, parasitic

ASJC Scopus subject areas

  • Parasitology
  • Immunology
  • Infectious Diseases


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