Plasmonic nanoprobes for stimulated emission depletion microscopy

Emiliano Cortes, Paloma A. Huidobro, Hugo G. Sinclair, Stina Guldbrand, William J. Peveler, Timothy Davies, Simona Parrinello, Frederik Görlitz, Chris Dunsby, Mark A. A. Neil, Yonatan Sivan, Ivan P. Parkin, Paul M. French, Stefan A. Maier

Research output: Contribution to journalArticlepeer-review


Plasmonic nanoparticles influence the absorption and emission processes of nearby emitters due to local enhancements of the illuminating radiation and the photonic density of states. Here, we use the plasmon resonance of metal nanoparticles in order to enhance the stimulated depletion of excited molecules for super-resolved microscopy. We demonstrate stimulated emission depletion (STED) microscopy with gold nanorods with a long axis of only 26 nm and a width of 8 nm that provide an enhancement of the resolution compared to fluorescent-only probes without plasmonic components irradiated with the same depletion power. These novel nanoparticle-assisted STED probes represent a ~2x10^3 reduction in probe volume compared to previously used nanoparticles and we demonstrate their application to the first plasmon-assisted STED cellular imaging. We also discuss their current limitations.Comment: 30 pages, 15 figures, main text and supplementary informatio
Original languageEnglish GB
JournalACS Nano
StatePublished - 5 Oct 2016


  • Physics - Optics
  • Physics - Chemical Physics


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