Plasmonic Photothermal Gold Bipyramid Nanoreactors for Ultrafast Real-Time Bioassays

Jung Hoon Lee, Zoya Cheglakov, Jaeseok Yi, Timothy M. Cronin, Kyle J. Gibson, Bozhi Tian, Yossi Weizmann

Research output: Contribution to journalArticlepeer-review

92 Scopus citations

Abstract

Nucleic acid amplification techniques have been among the most powerful tools for biological and biomedical research, and the vast majority of the bioassays rely on thermocycling that uses time-consuming and expensive Peltier-block heating. Here, we introduce a plasmonic photothermal method for quantitative real-time PCR, using gold bipyramids and light to achieve ultrafast thermocycling. Moreover, we successfully extend our photothermal system to other biological assays, such as isothermal nucleic acid amplification and restriction enzyme digestion.

Original languageEnglish
Pages (from-to)8054-8057
Number of pages4
JournalJournal of the American Chemical Society
Volume139
Issue number24
DOIs
StatePublished - 21 Jun 2017
Externally publishedYes

ASJC Scopus subject areas

  • Catalysis
  • General Chemistry
  • Biochemistry
  • Colloid and Surface Chemistry

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