| Original language | English |
|---|---|
| Title of host publication | Commission of the European Communities, (Report) EUR |
| Publisher | Commission of the European Communities by Pergamon Press |
| Pages | 789-795 |
| Number of pages | 7 |
| ISBN (Print) | 0080299776, 9780080299778 |
| DOIs | |
| State | Published - 1 Jan 1983 |
Publication series
| Name | Commission of the European Communities, (Report) EUR |
|---|---|
| Volume | 2 |
ASJC Scopus subject areas
- General Engineering
Access to Document
Other files and links
Cite this
- APA
- Author
- BIBTEX
- Harvard
- Standard
- RIS
- Vancouver
}
Commission of the European Communities, (Report) EUR. Commission of the European Communities by Pergamon Press, 1983. p. 789-795 (Commission of the European Communities, (Report) EUR; Vol. 2).
Research output: Chapter in Book/Report/Conference proceeding › Conference contribution › peer-review
TY - GEN
T1 - PLASTIC FLOW AND FRACTURE OF Ti - MODIFIED 316 AUSTENITIC STAINLESS STEEL AFTER HIGH TEMPERATURE AGING IN HYDROGEN.
AU - Mark-Markowitch, M.
AU - Rosenthal, Y.
AU - Stern, A.
AU - Eliezer, D.
N1 - Funding Information: soriasis is a common benign hyperproliferative skin dis-ease, characterized by an abnormal pattern of keratino-cyte growth and differentiation, invasion of an inflam-matory infiltrate into both the dermis and epidermis, P and morphologic changes in the dermal capillary network [ 1]. The molecular etiology of the disease is not understood, though cytokines mediating their response via protein kinase C have been hypothesized to alter the growth characteristics of psoriatic keratinocytes [2]. The transforming growth factors are known to regulate both keratinocyte growth and differentiation [3] and TGFalpha, which is rresent in normal adult epidermis [4], is elevated in the epidermis o psoriatic plaques [5]. Here we show by a combination of in situ hybridization and immunohistochemistry that the elevated expression of TGF-alfha RNA is localized specifically to the high-level keratinocytes o the epidermis in psoriatic plaques. Transforming growth factor-alpha (TGF-alpha) is a 50-amino acid polypeptide which is involved in the regulation of both growth and differentiation of epithelial cells [6 ]. It is a structural homologue of epidermal growth factor (EGF) and effects its responses via the EGF receptor. In psoriatic skin EGF receptors are present in all viable layers of the epidermis as compared to normal skin where rhey are mainly restricted to the basal and parabasallayers [7,8]. This loss of EGF receptor down-regulation in differentiating psoriatic keratinocytes is accompanied by an increase in the numbers of cells replicating DNA in the basal and immediately suprabasal layers. Uninvolved psoriatic epidermis also shows some persistent expres- Manuscript received October 25, 1989; accepted for publication November 29, 1989. This work was supported by a grant from the Wellcome Trust. Reprint requests to: Professor R. MacKie, Dept. of Dermatology, University of Glasgow, Anderson College, Building 56, Dumbarton Road, Glasgow, G11 6NU, Scotland. Abbreviations: DNA: deoxyribonucleic acid EGF: epidermal growth factor mRNA: messenger ribonucleic acid SSC: saline sodium citrate TGF-alpha: transforming growth factor-alpha
PY - 1983/1/1
Y1 - 1983/1/1
UR - http://www.scopus.com/inward/record.url?scp=0020501262&partnerID=8YFLogxK
U2 - 10.1016/b978-1-4832-8374-6.50114-3
DO - 10.1016/b978-1-4832-8374-6.50114-3
M3 - Conference contribution
AN - SCOPUS:0020501262
SN - 0080299776
SN - 9780080299778
T3 - Commission of the European Communities, (Report) EUR
SP - 789
EP - 795
BT - Commission of the European Communities, (Report) EUR
PB - Commission of the European Communities by Pergamon Press
ER -