Platelet adenylate cyclase activity in israeli victims of iraqi Scud missile attacks with post-traumatic stress disorder

Ronit Weizmann; Eitan Gur; Nathaniel Laor; Ahuva Reiss; Uri Muller; Alexander Yoresh; Bernard Lerer; Michael E. Newman

doi:10.1007/BF02249343

Platelet adenylate cyclase activity in israeli victims of iraqi Scud missile attacks with post-traumatic stress disorder

Ronit Weizmann, Eitan Gur, Nathaniel Laor, Ahuva Reiss, Uri Muller, Alexander Yoresh, Bernard Lerer, Michael E. Newman

Research output: Contribution to journal › Article › peer-review

9 Scopus citations

Abstract

Platelet adenylate cyclase activity was measured in 16 control subjects and 16 patients who developed post-traumatic stress disorder (PTSD) as a result of damage inflicted on their homes during the Iraqi Scud missile attacks on Israel which occurred during the 1991 Gulf War. There were no differences in basal, NaF-stimulated, PGE₁-stimulated or forskolin-stimulated activity between controls and PTSD subjects. Epinephrine inhibition of forskolin-stimulated activity, an effect mediated by alpha₂ adrenergic receptors, was slightly but not significantly increased in the PTSD patients compared to the controls, while 5-HT induced inhibition, an effect mediated by putative 5-HT_1a -like receptors, was unchanged. The relationship of these activities to measures of anxiety and depression in these patients is discussed.

Original language	English
Pages (from-to)	509-512
Number of pages	4
Journal	Psychopharmacology
Volume	114
Issue number	3
DOIs	https://doi.org/10.1007/BF02249343
State	Published - 1 Jan 1994
Externally published	Yes

Keywords

Adenylate cyclase Epinephrine
Platelet
Stress

ASJC Scopus subject areas

Pharmacology

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10.1007/BF02249343

Cite this

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abstract = "Platelet adenylate cyclase activity was measured in 16 control subjects and 16 patients who developed post-traumatic stress disorder (PTSD) as a result of damage inflicted on their homes during the Iraqi Scud missile attacks on Israel which occurred during the 1991 Gulf War. There were no differences in basal, NaF-stimulated, PGE1-stimulated or forskolin-stimulated activity between controls and PTSD subjects. Epinephrine inhibition of forskolin-stimulated activity, an effect mediated by alpha2 adrenergic receptors, was slightly but not significantly increased in the PTSD patients compared to the controls, while 5-HT induced inhibition, an effect mediated by putative 5-HT1a -like receptors, was unchanged. The relationship of these activities to measures of anxiety and depression in these patients is discussed.",

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AU - Weizmann, Ronit

AU - Gur, Eitan

AU - Laor, Nathaniel

AU - Reiss, Ahuva

AU - Muller, Uri

AU - Yoresh, Alexander

AU - Lerer, Bernard

AU - Newman, Michael E.

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AB - Platelet adenylate cyclase activity was measured in 16 control subjects and 16 patients who developed post-traumatic stress disorder (PTSD) as a result of damage inflicted on their homes during the Iraqi Scud missile attacks on Israel which occurred during the 1991 Gulf War. There were no differences in basal, NaF-stimulated, PGE1-stimulated or forskolin-stimulated activity between controls and PTSD subjects. Epinephrine inhibition of forskolin-stimulated activity, an effect mediated by alpha2 adrenergic receptors, was slightly but not significantly increased in the PTSD patients compared to the controls, while 5-HT induced inhibition, an effect mediated by putative 5-HT1a -like receptors, was unchanged. The relationship of these activities to measures of anxiety and depression in these patients is discussed.

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Platelet adenylate cyclase activity in israeli victims of iraqi Scud missile attacks with post-traumatic stress disorder

Abstract

Keywords

ASJC Scopus subject areas

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