Platelet Aggregability, Disaggregability and Serotonin Uptake in Migraine

L. Kruglak, Ilana Nathan, A. Korczyn, Z. Zolotov, V. Berginer, A. Dvilansky

Research output: Contribution to journalArticlepeer-review

17 Scopus citations

Abstract

Several disturbances in platelet function have been reported in migraineurs including serotonin (5–HT) metabolism and abnormal aggregability of platelets. The present work compared platelets taken from migraineurs during attacks and at headache-free periods with those of controls. The results demonstrated a tendency to increased aggregability during attacks compared to headache-free periods, and lower still in controls. Kinetic analysis of 5–HT uptake revealed normal K, increased V values and lower imipramine inhibition in m max migraineurs (both during headache and at headache-free periods). However, although the differences were significant statistically, they were small, and their clinical relevance remains to be proven.

Original languageEnglish
Pages (from-to)221-225
Number of pages5
JournalCephalalgia
Volume4
Issue number4
DOIs
StatePublished - 1 Jan 1984
Externally publishedYes

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