Platelet monoamine oxidase in affective illness and alcoholism

R. H. Belmaker, H. S. Bracha, R. P. Ebstein

Research output: Contribution to journalArticlepeer-review

31 Scopus citations


The authors review the literature on the relationship of platelet monoamine oxidase (MAO) to affective disorders and alcoholism. Although some studies have reported an association between low platelet MAO and bipolar illness, others have failed to replicate this finding. Alcoholism has been related to affective disorders, and it is of note that three studies have found low MAO in alcoholics. Given the physiological consequences of alcoholism, however, the interpretation of these findings is unclear. The authors conclude that non-specificity of low platelet MAO as a possible correlate of bipolar affective disorder, as well as schizophrenia, increases the burden of proof necessary before findings of low platelet MAO can be accepted as primary.

Original languageEnglish
Pages (from-to)320-323
Number of pages4
JournalSchizophrenia Bulletin
Issue number2
StatePublished - 1 Jan 1980
Externally publishedYes

ASJC Scopus subject areas

  • Psychiatry and Mental health


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