Pneumococcal resistance and serotype 19a in Pittsburgh-area children with acute otitis media before and after introduction of 7-valent Pneumococcal polysaccharide vaccine

Alejandro Hoberman, Jack L. Paradise, Nader Shaikh, David P. Greenberg, Diana H. Kearney, D. Kathleen Colborn, Howard E. Rockette, Marcia Kurs-Lasky, M. Catherine McEllistrem, Lisa M. Zoffel, Tracy L. Balentine, Karen A. Barbadora, Ellen R. Wald

Research output: Contribution to journalArticlepeer-review

20 Scopus citations

Abstract

Methods: Before and after introduction of pneumococcal conjugate vaccine (PCV7), the authors obtained nasopharyngeal (NP) specimens from 3 groups of children aged 6 to 23 months with acute otitis media (AOM): group 1 (pre-PCV7), group 2 (early post-PCV7), and group 3 (late post-PCV7). Results: Of the Streptococcus pneumoniae isolates, the proportion that were vaccine serotypes (VTs) declined progressively (60.4% vs 48.6% vs 5.2% in groups 1, 2, and 3, respectively; P <.001). Concurrently, increases occurred in the proportion of penicillin-nonsusceptible isolates (minimum inhibitory concentration >0.1 μg/mL; 26.7% vs 37.8% vs. 38.5%; P =.12); the proportion of isolates that were serotype 19A (4.0% vs 0% vs 25.9%; P <.001); and the proportion of 19A isolates that were penicillin-nonsusceptible (0% in group 1, 68.6% in group 3; P =.004). Conclusion: Shifts in pneumococcal serotype distribution and increases in penicillin nonsusceptibility among pneumococcal isolates from children with AOM underscore the need for continuing bacteriological surveillance for future vaccine development.

Original languageEnglish
Pages (from-to)114-120
Number of pages7
JournalClinical Pediatrics
Volume50
Issue number2
DOIs
StatePublished - 1 Feb 2011
Externally publishedYes

Keywords

  • Streptococcus pneumoniae
  • acute otitis media (AOM)
  • antimicrobial resistance
  • nasopharyngeal colonization

ASJC Scopus subject areas

  • Pediatrics, Perinatology, and Child Health

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