PO3-9: Effects of endurance training on somatic growth in a rat model of chronic kidney disease (CKD)

Daniel Landau; Maayan Guterman; Ari Yahalom; Ariel Troib; Ralph Rabkin; Yael Segev

doi:10.1530/boneabs.2.P24

PO3-9: Effects of endurance training on somatic growth in a rat model of chronic kidney disease (CKD)

Daniel Landau, Maayan Guterman, Ari Yahalom, Ariel Troib, Ralph Rabkin, Yael Segev

Research output: Contribution to conference › Paper › peer-review

Abstract

Background / Purpose: Resistance to the effects of growth hormone (GH) leads to suppressed body growth in children with chronic kidney disease (CKD). Physical activity has been previously shown to lead to over expression of growth factors in muscles of rats with CKD, but the effects of this intervention on bone tissue have not been investigated yet.The purpose of this study was to examine the effects of aerobic exercise on CKD related bone disease. Main conclusion: CKD induces growth retardation irrespective of food intake, associated with widened epiphyseal growth plate (EGP) hypertrophic zone but less vascularization, hinting for a chondrocyte maturation arrest. Endurance training did not rescue CKD somatic growth retardation, but longitudinal bone formation (as reflected by EGP histomorphometry) was better organized.

Original language	English
DOIs	https://doi.org/10.1530/boneabs.2.P24
State	Published - 15 Jul 2013

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title = "PO3-9: Effects of endurance training on somatic growth in a rat model of chronic kidney disease (CKD)",

abstract = "Background / Purpose: Resistance to the effects of growth hormone (GH) leads to suppressed body growth in children with chronic kidney disease (CKD). Physical activity has been previously shown to lead to over expression of growth factors in muscles of rats with CKD, but the effects of this intervention on bone tissue have not been investigated yet.The purpose of this study was to examine the effects of aerobic exercise on CKD related bone disease. Main conclusion: CKD induces growth retardation irrespective of food intake, associated with widened epiphyseal growth plate (EGP) hypertrophic zone but less vascularization, hinting for a chondrocyte maturation arrest. Endurance training did not rescue CKD somatic growth retardation, but longitudinal bone formation (as reflected by EGP histomorphometry) was better organized.",

author = "Daniel Landau and Maayan Guterman and Ari Yahalom and Ariel Troib and Ralph Rabkin and Yael Segev",

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T1 - PO3-9: Effects of endurance training on somatic growth in a rat model of chronic kidney disease (CKD)

AU - Landau, Daniel

AU - Guterman, Maayan

AU - Yahalom, Ari

AU - Troib, Ariel

AU - Rabkin, Ralph

AU - Segev, Yael

PY - 2013/7/15

Y1 - 2013/7/15

N2 - Background / Purpose: Resistance to the effects of growth hormone (GH) leads to suppressed body growth in children with chronic kidney disease (CKD). Physical activity has been previously shown to lead to over expression of growth factors in muscles of rats with CKD, but the effects of this intervention on bone tissue have not been investigated yet.The purpose of this study was to examine the effects of aerobic exercise on CKD related bone disease. Main conclusion: CKD induces growth retardation irrespective of food intake, associated with widened epiphyseal growth plate (EGP) hypertrophic zone but less vascularization, hinting for a chondrocyte maturation arrest. Endurance training did not rescue CKD somatic growth retardation, but longitudinal bone formation (as reflected by EGP histomorphometry) was better organized.

AB - Background / Purpose: Resistance to the effects of growth hormone (GH) leads to suppressed body growth in children with chronic kidney disease (CKD). Physical activity has been previously shown to lead to over expression of growth factors in muscles of rats with CKD, but the effects of this intervention on bone tissue have not been investigated yet.The purpose of this study was to examine the effects of aerobic exercise on CKD related bone disease. Main conclusion: CKD induces growth retardation irrespective of food intake, associated with widened epiphyseal growth plate (EGP) hypertrophic zone but less vascularization, hinting for a chondrocyte maturation arrest. Endurance training did not rescue CKD somatic growth retardation, but longitudinal bone formation (as reflected by EGP histomorphometry) was better organized.

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DO - 10.1530/boneabs.2.P24

M3 - Paper

ER -

PO3-9: Effects of endurance training on somatic growth in a rat model of chronic kidney disease (CKD)

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