Background / Purpose: Resistance to the effects of growth hormone (GH) leads to suppressed body growth in children with chronic kidney disease (CKD). Physical activity has been previously shown to lead to over expression of growth factors in muscles of rats with CKD, but the effects of this intervention on bone tissue have not been investigated yet.The purpose of this study was to examine the effects of aerobic exercise on CKD related bone disease. Main conclusion: CKD induces growth retardation irrespective of food intake, associated with widened epiphyseal growth plate (EGP) hypertrophic zone but less vascularization, hinting for a chondrocyte maturation arrest. Endurance training did not rescue CKD somatic growth retardation, but longitudinal bone formation (as reflected by EGP histomorphometry) was better organized.
|State||Published - 15 Jul 2013|