Polyanhydrides for controlled release of bioactive agents

K. W. Leong; J. Kost; E. Mathiowitz; R. Langer

doi:10.1016/0142-9612(86)90007-4

Polyanhydrides for controlled release of bioactive agents

K. W. Leong, J. Kost, E. Mathiowitz, R. Langer

Department of Chemical Engineering

Research output: Contribution to journal › Article › peer-review

107 Scopus citations

Abstract

This report is a review of the development of a drug delivery system based on bioerodible polyanhydrides. With the water labile anhydride linkage, a wide range of matrix degradation and drug release rates can be obtained from these drug-carriers. In addition to monolithic formulations, the feasibility of an injectable system by microencapsulation is demonstrated. The possibility of enhancing the release externally by an ultrasonic source has also been explored. The polymers tested showed good tissue biocompatibility and their breakdown products showed no adverse toxicological effects. Preliminary in vivo results confirmed the efficacy of these devices.

Original language	English
Pages (from-to)	364-371
Number of pages	8
Journal	Biomaterials
Volume	7
Issue number	5
DOIs	https://doi.org/10.1016/0142-9612(86)90007-4
State	Published - 1 Jan 1986

Keywords

Drug-carriers
controlled release
drug delivery
polyanhydride

ASJC Scopus subject areas

Biophysics
Bioengineering
Ceramics and Composites
Biomaterials
Mechanics of Materials

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10.1016/0142-9612(86)90007-4

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title = "Polyanhydrides for controlled release of bioactive agents",

abstract = "This report is a review of the development of a drug delivery system based on bioerodible polyanhydrides. With the water labile anhydride linkage, a wide range of matrix degradation and drug release rates can be obtained from these drug-carriers. In addition to monolithic formulations, the feasibility of an injectable system by microencapsulation is demonstrated. The possibility of enhancing the release externally by an ultrasonic source has also been explored. The polymers tested showed good tissue biocompatibility and their breakdown products showed no adverse toxicological effects. Preliminary in vivo results confirmed the efficacy of these devices.",

keywords = "Drug-carriers, controlled release, drug delivery, polyanhydride",

author = "Leong, {K. W.} and J. Kost and E. Mathiowitz and R. Langer",

note = "Funding Information: This work was supported by NIH Grant No. 26698. The authors gratefully acknowledge the following individuals: B. Brott and V. Simonte for technical support; Drs P. D{\textquoteright}Amore, A. Braun, H. Lieber, J. Sudhalter for the toxicological evaluations; Drs D. Lund and J. Folkman for the angiogenesis experiments.",

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doi = "10.1016/0142-9612(86)90007-4",

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T1 - Polyanhydrides for controlled release of bioactive agents

AU - Leong, K. W.

AU - Kost, J.

AU - Mathiowitz, E.

AU - Langer, R.

N1 - Funding Information: This work was supported by NIH Grant No. 26698. The authors gratefully acknowledge the following individuals: B. Brott and V. Simonte for technical support; Drs P. D’Amore, A. Braun, H. Lieber, J. Sudhalter for the toxicological evaluations; Drs D. Lund and J. Folkman for the angiogenesis experiments.

PY - 1986/1/1

Y1 - 1986/1/1

N2 - This report is a review of the development of a drug delivery system based on bioerodible polyanhydrides. With the water labile anhydride linkage, a wide range of matrix degradation and drug release rates can be obtained from these drug-carriers. In addition to monolithic formulations, the feasibility of an injectable system by microencapsulation is demonstrated. The possibility of enhancing the release externally by an ultrasonic source has also been explored. The polymers tested showed good tissue biocompatibility and their breakdown products showed no adverse toxicological effects. Preliminary in vivo results confirmed the efficacy of these devices.

AB - This report is a review of the development of a drug delivery system based on bioerodible polyanhydrides. With the water labile anhydride linkage, a wide range of matrix degradation and drug release rates can be obtained from these drug-carriers. In addition to monolithic formulations, the feasibility of an injectable system by microencapsulation is demonstrated. The possibility of enhancing the release externally by an ultrasonic source has also been explored. The polymers tested showed good tissue biocompatibility and their breakdown products showed no adverse toxicological effects. Preliminary in vivo results confirmed the efficacy of these devices.

KW - Drug-carriers

KW - controlled release

KW - drug delivery

KW - polyanhydride

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U2 - 10.1016/0142-9612(86)90007-4

DO - 10.1016/0142-9612(86)90007-4

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VL - 7

SP - 364

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JO - Biomaterials

JF - Biomaterials

IS - 5

ER -

Polyanhydrides for controlled release of bioactive agents

Abstract

Keywords

ASJC Scopus subject areas

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