Polycomb repressive complex(Es) and their role in adult stem cells

Pooja Flora, Gil Dalal, Idan Cohen, Elena Ezhkova

Research output: Contribution to journalReview articlepeer-review

Abstract

Populations of resident stem cells (SCs) are responsible for maintaining, repairing, and regenerating adult tissues. In addition to having the capacity to generate all the differentiated cell types of the tissue, adult SCs undergo long periods of quiescence within the niche to maintain themselves. The process of SC renewal and differentiation is tightly regulated for proper tissue regeneration throughout an organisms’ lifetime. Epigenetic regulators, such as the polycomb group (PcG) of proteins have been implicated in modulating gene expression in adult SCs to maintain homeostatic and regenerative balances in adult tissues. In this review, we summarize the recent findings that elucidate the composition and function of the polycomb repressive complex machinery and highlight their role in diverse adult stem cell compartments.

Original languageEnglish
Article number1485
JournalGenes
Volume12
Issue number10
DOIs
StatePublished - 1 Oct 2021

Keywords

  • Adult stem cells
  • Histone modifications
  • PRC1
  • PRC2
  • Polycomb complexes

ASJC Scopus subject areas

  • Genetics
  • Genetics(clinical)

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