Poly(d2NH2A-dT): Effect of 2-amino substituent on the B to Z transition

Frank B. Howard; Chi wan Chen; Jack S. Cohen; H. Todd Miles

doi:10.1016/0006-291X(84)91472-4

Poly(d2NH₂A-dT): Effect of 2-amino substituent on the B to Z transition

Frank B. Howard, Chi wan Chen, Jack S. Cohen, H. Todd Miles

Research output: Contribution to journal › Article › peer-review

34 Scopus citations

Abstract

The effect of 2-amino substitution in adenosine (which permits formation of three hydrogen bonds to T) on the B to Z transition was examined in synthetic DNA of alternating purine-pyrimidine sequence. Results of CD, IR, and ³¹P NMR experiments show that (d2NH₂A-dT)_n undergoes a cooperative transition to a different helical structure under the same conditions as the B to Z transition of (dG-dC)_n.

Original language	English
Pages (from-to)	848-853
Number of pages	6
Journal	Biochemical and Biophysical Research Communications
Volume	118
Issue number	3
DOIs	https://doi.org/10.1016/0006-291X(84)91472-4
State	Published - 14 Feb 1984
Externally published	Yes

ASJC Scopus subject areas

Biophysics
Biochemistry
Molecular Biology
Cell Biology

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10.1016/0006-291X(84)91472-4

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abstract = "The effect of 2-amino substitution in adenosine (which permits formation of three hydrogen bonds to T) on the B to Z transition was examined in synthetic DNA of alternating purine-pyrimidine sequence. Results of CD, IR, and 31P NMR experiments show that (d2NH2A-dT)n undergoes a cooperative transition to a different helical structure under the same conditions as the B to Z transition of (dG-dC)n.",

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AU - Chen, Chi wan

AU - Cohen, Jack S.

AU - Miles, H. Todd

PY - 1984/2/14

Y1 - 1984/2/14

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AB - The effect of 2-amino substitution in adenosine (which permits formation of three hydrogen bonds to T) on the B to Z transition was examined in synthetic DNA of alternating purine-pyrimidine sequence. Results of CD, IR, and 31P NMR experiments show that (d2NH2A-dT)n undergoes a cooperative transition to a different helical structure under the same conditions as the B to Z transition of (dG-dC)n.

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Poly(d2NH₂A-dT): Effect of 2-amino substituent on the B to Z transition

Abstract

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