Polyethersulfone-carbon nanotubes composite hollow fiber membranes with improved biocompatibility for bioartificial liver

Surendra Kumar Verma, Akshay Modi, Jayesh Bellare

Research output: Contribution to journalArticlepeer-review

21 Scopus citations

Abstract

Carbon nanotubes (CNTs) blended hollow fiber membranes (HFMs) are a promising new material in the area of biomedical engineering because they simultaneously provide tunable hydrophilicity along with selective permeability. In the present study, composite polyethersulfone (P) HFMs were fabricated using d-α-tocopheryl polyethylene glycol 1000 succinate (TPGS or T) as compatibilizer, and carboxylated multiwalled CNTs (MWCNTs or C) as filler. The amount of MWCNTs was optimized for the improved hemocompatibility, cell viability, and cellular functionality. An optimum was found with the composte HFMs (PTC-2), where MWCNTs were used at concentration of 0.030 wt.%, as it exhibited improved compatibility with human blood. Further, these PTC-2 HFMs showed enhanced liver (HepG2) cells growth with the enhanced cell functional activities, mainly albumin secretion and glucose consumption. These developed composite membrane can act as a membrane material for liver cell bioreactor and bioartificial liver development because of their 3D scaffold like characteristic which enables cell growth, and selective permeability which helps in immunoisolation.

Original languageEnglish
Pages (from-to)890-895
Number of pages6
JournalColloids and Surfaces B: Biointerfaces
Volume181
DOIs
StatePublished - 1 Sep 2019
Externally publishedYes

Keywords

  • Carboxylated multiwalled carbon nanotubes
  • Hydrophilicity
  • Liver cells study
  • Polyethersulfone composite hollow fiber membranes
  • Pure water permeability

ASJC Scopus subject areas

  • Biotechnology
  • Surfaces and Interfaces
  • Physical and Theoretical Chemistry
  • Colloid and Surface Chemistry

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