Polymorph IV of 4-amino-N-2-pyridinylbenzenesulfonamide (sulfapyridine).

J. Bernstein

doi:10.1107/s0108270188001180

Polymorph IV of 4-amino-N-2-pyridinylbenzenesulfonamide (sulfapyridine).

J. Bernstein

Department of Chemistry

Research output: Contribution to journal › Article › peer-review

24 Scopus citations

Abstract

C11H11N3O2S, Mr = 249.3, monoclinic, P2(1)/c, a = 13.56 (4), b = 6.48 (1), c = 14.12 (3) A, beta = 113.7 (1) degrees, V = 1136.4 (44) A3, Z = 4, D chi = 1.457 g cm-3, lambda(Mo K alpha) = 0.70926 A, mu = 2.29 cm-1, F(000) = 520, T = 291 K, final R = 0.085 for 1287 independent observed reflections. Sulfapyridine is a sulfonamide drug with antibacterial, antithyroid and antidiabetic properties. The molecule exhibits the same conformation as in all except one of the polymorphs previously studied, despite a hydrogen-bonded packing mode which differs from that observed in the three earlier reported polymorphs. Form IV exhibits three hydrogen bonds of the type N...N = 2.91 (1) A and N...O = 3.007 (7) and 3.076 (7) A.

Original language	English
Pages (from-to)	900-902
Number of pages	3
Journal	Acta Crystallographica Section C: Crystal Structure Communications
Volume	44 ( Pt 5)
DOIs	https://doi.org/10.1107/s0108270188001180
State	Published - 1 Jan 1988

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General Biochemistry, Genetics and Molecular Biology

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title = "Polymorph IV of 4-amino-N-2-pyridinylbenzenesulfonamide (sulfapyridine).",

abstract = "C11H11N3O2S, Mr = 249.3, monoclinic, P2(1)/c, a = 13.56 (4), b = 6.48 (1), c = 14.12 (3) A, beta = 113.7 (1) degrees, V = 1136.4 (44) A3, Z = 4, D chi = 1.457 g cm-3, lambda(Mo K alpha) = 0.70926 A, mu = 2.29 cm-1, F(000) = 520, T = 291 K, final R = 0.085 for 1287 independent observed reflections. Sulfapyridine is a sulfonamide drug with antibacterial, antithyroid and antidiabetic properties. The molecule exhibits the same conformation as in all except one of the polymorphs previously studied, despite a hydrogen-bonded packing mode which differs from that observed in the three earlier reported polymorphs. Form IV exhibits three hydrogen bonds of the type N...N = 2.91 (1) A and N...O = 3.007 (7) and 3.076 (7) A.",

author = "J. Bernstein",

year = "1988",

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doi = "10.1107/s0108270188001180",

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journal = "Acta Crystallographica Section C: Crystal Structure Communications",

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T1 - Polymorph IV of 4-amino-N-2-pyridinylbenzenesulfonamide (sulfapyridine).

AU - Bernstein, J.

PY - 1988/1/1

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N2 - C11H11N3O2S, Mr = 249.3, monoclinic, P2(1)/c, a = 13.56 (4), b = 6.48 (1), c = 14.12 (3) A, beta = 113.7 (1) degrees, V = 1136.4 (44) A3, Z = 4, D chi = 1.457 g cm-3, lambda(Mo K alpha) = 0.70926 A, mu = 2.29 cm-1, F(000) = 520, T = 291 K, final R = 0.085 for 1287 independent observed reflections. Sulfapyridine is a sulfonamide drug with antibacterial, antithyroid and antidiabetic properties. The molecule exhibits the same conformation as in all except one of the polymorphs previously studied, despite a hydrogen-bonded packing mode which differs from that observed in the three earlier reported polymorphs. Form IV exhibits three hydrogen bonds of the type N...N = 2.91 (1) A and N...O = 3.007 (7) and 3.076 (7) A.

AB - C11H11N3O2S, Mr = 249.3, monoclinic, P2(1)/c, a = 13.56 (4), b = 6.48 (1), c = 14.12 (3) A, beta = 113.7 (1) degrees, V = 1136.4 (44) A3, Z = 4, D chi = 1.457 g cm-3, lambda(Mo K alpha) = 0.70926 A, mu = 2.29 cm-1, F(000) = 520, T = 291 K, final R = 0.085 for 1287 independent observed reflections. Sulfapyridine is a sulfonamide drug with antibacterial, antithyroid and antidiabetic properties. The molecule exhibits the same conformation as in all except one of the polymorphs previously studied, despite a hydrogen-bonded packing mode which differs from that observed in the three earlier reported polymorphs. Form IV exhibits three hydrogen bonds of the type N...N = 2.91 (1) A and N...O = 3.007 (7) and 3.076 (7) A.

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SN - 0108-2701

VL - 44 ( Pt 5)

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JO - Acta Crystallographica Section C: Crystal Structure Communications

JF - Acta Crystallographica Section C: Crystal Structure Communications

ER -

Polymorph IV of 4-amino-N-2-pyridinylbenzenesulfonamide (sulfapyridine).

Abstract

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