Population structure of group B streptococcus from a low-incidence region for invasive neonatal disease

Naiel Bisharat, Nicola Jones, Dror Marchaim, Colin Block, Rosalind M. Harding, Pablo Yagupsky, Tim Peto, Derrick W. Crook

Research output: Contribution to journalArticlepeer-review

45 Scopus citations

Abstract

The population structure of group B streptococcus (GBS) from a low-incidence region for invasive neonatal disease (Israel) was investigated using multilocus genotype data. The strain collection consisted of isolates from maternal carriage (n = 104) and invasive neonatal disease (n = 50), resolving into 46 sequence types. The most prevalent sequence types were ST-1 (17.5%), ST-19 (10.4%), ST-17 (9.7%), ST-22 (8.4%) and ST-23 (6.5%). Serotype III was the most common, accounting for 29.2% of the isolates. None of the serotypes was significantly associated with invasive neonatal disease. BURST analysis resolved the 46 sequence types into seven lineages (clonal complexes), from which only lineage ST-17, expressing serotype III only, was significantly associated with invasive neonatal disease. Lineage ST-22 expressed mainly serotype II, and was significantly associated with carriage. The distribution of the various sequence types and lineages, and the association of lineage ST-17 with invasive disease, are consistent with the results of analyses from a global GBS isolate collection. These findings could imply that the global variation in disease incidence is independent of the circulating GBS populations, and may be more affected by other risk factors for invasive GBS disease, or by different prevention strategies.

Original languageEnglish
Pages (from-to)1875-1881
Number of pages7
JournalMicrobiology
Volume151
Issue number6
DOIs
StatePublished - 1 Jun 2005

ASJC Scopus subject areas

  • Microbiology

Fingerprint

Dive into the research topics of 'Population structure of group B streptococcus from a low-incidence region for invasive neonatal disease'. Together they form a unique fingerprint.

Cite this