Positive placental staining for alkaline phosphatase corresponding with extreme elevation of serum alkaline phosphatase during pregnancy

Asher Bashiri, Ohad Katz, Esther Maor, Eyal Sheiner, Izak Pack, Moshe Mazor

Research output: Contribution to journalArticlepeer-review

21 Scopus citations

Abstract

Placental ALP (ALPh) is a membrane-anchored, heat-stable enzyme produced by the syncytiotrophoblast. We report a case of a patient presenting in the third trimester with extreme increased levels of ALPh. A 40-year-old woman, gravida 2, para 1, was admitted to the high risk pregnancy unit at 30 weeks of gestation for evaluation of an incidental finding of marked isolated elevation in serum ALPh. Blood tests obtained at admission revealed a marked elevation of serum ALP level up to 1,194 u/l (reference 35-104 u/l). At 36 weeks of gestation, the patient was admitted with preterm premature rupture of membranes. Due to breech presentation, a cesarean delivery was performed. An immunoperoxidase stain was done for placental alkaline phosphatase, which was positive in the majority of chorionic trophoblastic cells. No evidence of inflammation was detected in the placental chorionic plate. Thus, isolated elevation in placental ALP may be linked to a subsequent preterm delivery.

Original languageEnglish
Pages (from-to)211-214
Number of pages4
JournalArchives of Gynecology and Obstetrics
Volume275
Issue number3
DOIs
StatePublished - 1 Mar 2007
Externally publishedYes

Keywords

  • Placenta
  • Placental alkaline phosphatase (ALP)
  • Preterm delivery

ASJC Scopus subject areas

  • Obstetrics and Gynecology

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