Possible common biomarkers from FTIR microspectroscopy of cervical cancer and melanoma

S. Mordechai; R. K. Sahu; Z. Hammody; S. Mark; K. Kantarovich; H. Guterman; A. Podshyvalov; J. Goldstein; S. Argov

doi:10.1111/j.0022-2720.2004.01356.x

Possible common biomarkers from FTIR microspectroscopy of cervical cancer and melanoma

S. Mordechai, R. K. Sahu, Z. Hammody, S. Mark, K. Kantarovich, H. Guterman, A. Podshyvalov, J. Goldstein, S. Argov

Research output: Contribution to journal › Article › peer-review

117 Scopus citations

Abstract

Detection of malignancy at early stages is crucial in cancer prevention and management. Fourier transform infrared (FTIR) spectroscopy has shown promise as a non-invasive method with diagnostic potential in cancer detection. Studies were conducted with formalin-fixed biopsies of melanoma and cervical cancer by FTIR microspectroscopy (FTIR-MSP) to detect common biomarkers, which occurred in both types of cancer distinguishing them from the respective non-malignant tissues. Both types of cancer are diagnosed on skin surfaces. The spectra were analysed for changes in levels of biomolecules such as RNA, DNA, phosphates and carbohydrate (glycogen). Whereas carbohydrate levels showed a good diagnostic potential for detection of cervical cancer, this was not the case for melanoma. However, variation of the RNA/DNA ratio as measured at I(1121)/I(1020) showed similar trends between non-malignant and malignant tissues in both types of cancer. The ratio was higher for malignant tissues in both types of cancer.

Original language	English
Pages (from-to)	86-91
Number of pages	6
Journal	Journal of Microscopy
Volume	215
Issue number	1
DOIs	https://doi.org/10.1111/j.0022-2720.2004.01356.x
State	Published - 1 Jan 2004

Keywords

Cervical cancer
Diagnosis
FTIR-MSP
Melanoma
RNA/DNA ratio

ASJC Scopus subject areas

Pathology and Forensic Medicine
Histology

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

Access to Document

10.1111/j.0022-2720.2004.01356.x

Cite this

@article{a88d1a06269f42e08561b1d147a40809,

title = "Possible common biomarkers from FTIR microspectroscopy of cervical cancer and melanoma",

abstract = "Detection of malignancy at early stages is crucial in cancer prevention and management. Fourier transform infrared (FTIR) spectroscopy has shown promise as a non-invasive method with diagnostic potential in cancer detection. Studies were conducted with formalin-fixed biopsies of melanoma and cervical cancer by FTIR microspectroscopy (FTIR-MSP) to detect common biomarkers, which occurred in both types of cancer distinguishing them from the respective non-malignant tissues. Both types of cancer are diagnosed on skin surfaces. The spectra were analysed for changes in levels of biomolecules such as RNA, DNA, phosphates and carbohydrate (glycogen). Whereas carbohydrate levels showed a good diagnostic potential for detection of cervical cancer, this was not the case for melanoma. However, variation of the RNA/DNA ratio as measured at I(1121)/I(1020) showed similar trends between non-malignant and malignant tissues in both types of cancer. The ratio was higher for malignant tissues in both types of cancer.",

keywords = "Cervical cancer, Diagnosis, FTIR-MSP, Melanoma, RNA/DNA ratio",

author = "S. Mordechai and Sahu, {R. K.} and Z. Hammody and S. Mark and K. Kantarovich and H. Guterman and A. Podshyvalov and J. Goldstein and S. Argov",

year = "2004",

month = jan,

day = "1",

doi = "10.1111/j.0022-2720.2004.01356.x",

language = "English",

volume = "215",

pages = "86--91",

journal = "Journal of Microscopy",

issn = "0022-2720",

publisher = "Wiley-Blackwell Publishing Ltd",

number = "1",

}

TY - JOUR

T1 - Possible common biomarkers from FTIR microspectroscopy of cervical cancer and melanoma

AU - Mordechai, S.

AU - Sahu, R. K.

AU - Hammody, Z.

AU - Mark, S.

AU - Kantarovich, K.

AU - Guterman, H.

AU - Podshyvalov, A.

AU - Goldstein, J.

AU - Argov, S.

PY - 2004/1/1

Y1 - 2004/1/1

N2 - Detection of malignancy at early stages is crucial in cancer prevention and management. Fourier transform infrared (FTIR) spectroscopy has shown promise as a non-invasive method with diagnostic potential in cancer detection. Studies were conducted with formalin-fixed biopsies of melanoma and cervical cancer by FTIR microspectroscopy (FTIR-MSP) to detect common biomarkers, which occurred in both types of cancer distinguishing them from the respective non-malignant tissues. Both types of cancer are diagnosed on skin surfaces. The spectra were analysed for changes in levels of biomolecules such as RNA, DNA, phosphates and carbohydrate (glycogen). Whereas carbohydrate levels showed a good diagnostic potential for detection of cervical cancer, this was not the case for melanoma. However, variation of the RNA/DNA ratio as measured at I(1121)/I(1020) showed similar trends between non-malignant and malignant tissues in both types of cancer. The ratio was higher for malignant tissues in both types of cancer.

AB - Detection of malignancy at early stages is crucial in cancer prevention and management. Fourier transform infrared (FTIR) spectroscopy has shown promise as a non-invasive method with diagnostic potential in cancer detection. Studies were conducted with formalin-fixed biopsies of melanoma and cervical cancer by FTIR microspectroscopy (FTIR-MSP) to detect common biomarkers, which occurred in both types of cancer distinguishing them from the respective non-malignant tissues. Both types of cancer are diagnosed on skin surfaces. The spectra were analysed for changes in levels of biomolecules such as RNA, DNA, phosphates and carbohydrate (glycogen). Whereas carbohydrate levels showed a good diagnostic potential for detection of cervical cancer, this was not the case for melanoma. However, variation of the RNA/DNA ratio as measured at I(1121)/I(1020) showed similar trends between non-malignant and malignant tissues in both types of cancer. The ratio was higher for malignant tissues in both types of cancer.

KW - Cervical cancer

KW - Diagnosis

KW - FTIR-MSP

KW - Melanoma

KW - RNA/DNA ratio

UR - http://www.scopus.com/inward/record.url?scp=3042598669&partnerID=8YFLogxK

U2 - 10.1111/j.0022-2720.2004.01356.x

DO - 10.1111/j.0022-2720.2004.01356.x

M3 - Article

C2 - 15230879

AN - SCOPUS:3042598669

SN - 0022-2720

VL - 215

SP - 86

EP - 91

JO - Journal of Microscopy

JF - Journal of Microscopy

IS - 1

ER -

Possible common biomarkers from FTIR microspectroscopy of cervical cancer and melanoma

Abstract

Keywords

ASJC Scopus subject areas

UN SDGs

Access to Document

Other files and links

Fingerprint

Cite this